caa a22 4500 465762816 CHVBK 20180323111904.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF00303281 doi (NATIONALLICENCE)springer-10.1007/BF00303281 Flow cytometric analysis in colorectal carcinoma: prognostic significance of cellular DNA content [Elektronische Daten] [A. Schillaci, D. Tirindelli, M. Ferri, L. Teodori, F. Mauro, V. Nicolanti, S. Stipa] The prognostic value of DNA ploidy status was evaluated prospectively in 70 patients with colorectal carcinoma. Cellular DNA content was measured by flow cytometry from fresh specimens with multiple site sampling. Seventy-five percent of cases exhibited a DNA aneuploid pattern. In a univariate analysis, DNA ploidy status showed a statistically significant correlation with survival (p<0.05), weaker than Dukes' stage (p<0.001). No correlation was observed between survival and presence of multiple DNA stemlines. In a multivariate analysis. Dukes' stage was the strongest prognostic indicator (p=0.01) while DNA ploidy status did not show an independent prognostic value. It is concluded that DNA ploidy status is associated with pathological features of aggressive malignancy, but it does not have a determinant role in predicting survival. Springer-Verlag, 1990 Schillaci A. Department of Surgery, University "La Sapienza”, Rome, Italy aut Tirindelli D. Division of Physics and Biomedical Sciences, ENEA, C.R.E., Casaccia, Rome, Italy aut Ferri M. Department of Surgery, University "La Sapienza”, Rome, Italy aut Teodori L. Division of Physics and Biomedical Sciences, ENEA, C.R.E., Casaccia, Rome, Italy aut Mauro F. Division of Physics and Biomedical Sciences, ENEA, C.R.E., Casaccia, Rome, Italy aut Nicolanti V. Department of Surgery, University "La Sapienza”, Rome, Italy aut Stipa S. Department of Surgery, University "La Sapienza”, Rome, Italy aut International Journal of Colorectal Disease Springer-Verlag 5/4(1990-12-01), 223-227 0179-1958 5:4<223 1990 5 384 https://doi.org/10.1007/BF00303281 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00303281 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schillaci A. Department of Surgery, University "La Sapienza”, Rome, Italy aut NATIONALLICENCE 700 1- Tirindelli D. Division of Physics and Biomedical Sciences, ENEA, C.R.E., Casaccia, Rome, Italy aut NATIONALLICENCE 700 1- Ferri M. Department of Surgery, University "La Sapienza”, Rome, Italy aut NATIONALLICENCE 700 1- Teodori L. Division of Physics and Biomedical Sciences, ENEA, C.R.E., Casaccia, Rome, Italy aut NATIONALLICENCE 700 1- Mauro F. Division of Physics and Biomedical Sciences, ENEA, C.R.E., Casaccia, Rome, Italy aut NATIONALLICENCE 700 1- Nicolanti V. Department of Surgery, University "La Sapienza”, Rome, Italy aut NATIONALLICENCE 700 1- Stipa S. Department of Surgery, University "La Sapienza”, Rome, Italy aut NATIONALLICENCE 773 0- International Journal of Colorectal Disease Springer-Verlag 5/4(1990-12-01), 223-227 0179-1958 5:4<223 1990 5 384 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer