caa a22 4500 465762980 CHVBK 20180323111904.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00298475 doi (NATIONALLICENCE)springer-10.1007/BF00298475 Primary and metastatic liver lesions of clinical colorectal cancer differ in chemosensitivity [Elektronische Daten] [Y. Maehara, Y. Sakaguchi, Y. Emi, T. Kusumoto, S. Kohnoe, M. Mori, K. Sugimachi] The succinate dehydrogenase inhibition (SDI) test was used to examine eight pairs of samples obtained simultaneously from primary colorectal cancers and metastatic liver lesions. The chemosensitivity of the metastatic lesions to six antitumour drugs, carboquone (CQ), adriamycin (ADM), mitomycin C (MMC), aclacinomycin A (ACR), cisplatin (DDP), and 5-fluorouracil (5-FU), differed from that of the primary lesions-the metastatic lesions were less sensitive to all these drugs. There were no correlations of chemosensitivities between the primary and the metastatic lesions (r=-0.4331∼0.4857). Thus, in patients with liver metastasis from a primary colorectal cancer, treatment with these drugs may not be so effective. When selecting antitumour drugs for metastatic liver lesions of colorectal cancer, the chemosensitivity of the primary tumour should first be assessed. Springer-Verlag, 1990 Maehara Y. Department of Surgery II of Kyushu University Hospital, Faculty of Medicine, Kyushu University, Fukuoka, Japan aut Sakaguchi Y. The Cancer Center of Kyushu University Hospital, Faculty of Medicine, Kyushu University, Fukuoka, Japan aut Emi Y. The Cancer Center of Kyushu University Hospital, Faculty of Medicine, Kyushu University, Fukuoka, Japan aut Kusumoto T. The Cancer Center of Kyushu University Hospital, Faculty of Medicine, Kyushu University, Fukuoka, Japan aut Kohnoe S. Department of Surgery II of Kyushu University Hospital, Faculty of Medicine, Kyushu University, Fukuoka, Japan aut Mori M. Department of Surgery II of Kyushu University Hospital, Faculty of Medicine, Kyushu University, Fukuoka, Japan aut Sugimachi K. Department of Surgery II of Kyushu University Hospital, Faculty of Medicine, Kyushu University, Fukuoka, Japan aut International Journal of Colorectal Disease Springer-Verlag 5/2(1990-05-01), 87-89 0179-1958 5:2<87 1990 5 384 https://doi.org/10.1007/BF00298475 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00298475 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maehara Y. Department of Surgery II of Kyushu University Hospital, Faculty of Medicine, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Sakaguchi Y. The Cancer Center of Kyushu University Hospital, Faculty of Medicine, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Emi Y. The Cancer Center of Kyushu University Hospital, Faculty of Medicine, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Kusumoto T. The Cancer Center of Kyushu University Hospital, Faculty of Medicine, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Kohnoe S. Department of Surgery II of Kyushu University Hospital, Faculty of Medicine, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Mori M. Department of Surgery II of Kyushu University Hospital, Faculty of Medicine, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Sugimachi K. Department of Surgery II of Kyushu University Hospital, Faculty of Medicine, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 773 0- International Journal of Colorectal Disease Springer-Verlag 5/2(1990-05-01), 87-89 0179-1958 5:2<87 1990 5 384 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer