caa a22 4500 465763057 CHVBK 20180323111904.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00298473 doi (NATIONALLICENCE)springer-10.1007/BF00298473 Topical treatment with 5-aminosalicylic in distal ulcerative colitis by using a new suppository preparation [Elektronische Daten] A double-blind placebo controlled trial [M. Campieri, P. Gionchetti, A. Belluzzi, C. Brignola, M. Tampieri, P. Iannone, P. Brunetti, M. Miglioli, L. Barbara] Sixty-two patients with ulcerative colitis localised to the distal sigmoid colon and rectum (<20 cm) entered the trial. Thirty-two were treated with 5-ASA 500 mg suppositories (Asacol) 3 times a day for 1 month while 30 received a placebo given in the same regime. Clinical, sigmoidoscopic and histological assessment was carried out before, after 15 days and after 1 month of treatment. At the end of the study 5-ASA suppositories showed significantly better results in all the parameters recorded than placebo (p<0.01). There were no unwanted effects related to the use of suppositories. This treatment should therefore be offered as a first choice for patients with distal rectosigmoiditis. Springer-Verlag, 1990 Campieri M. Institute of Clinical Medicine and Gastroenterology, University of Bologna, Italy aut Gionchetti P. Institute of Clinical Medicine and Gastroenterology, University of Bologna, Italy aut Belluzzi A. Institute of Clinical Medicine and Gastroenterology, University of Bologna, Italy aut Brignola C. Institute of Clinical Medicine and Gastroenterology, University of Bologna, Italy aut Tampieri M. Institute of Clinical Medicine and Gastroenterology, University of Bologna, Italy aut Iannone P. Institute of Clinical Medicine and Gastroenterology, University of Bologna, Italy aut Brunetti P. Giuliani Medical Department, Milano, Italy aut Miglioli M. Institute of Clinical Medicine and Gastroenterology, University of Bologna, Italy aut Barbara L. Institute of Clinical Medicine and Gastroenterology, University of Bologna, Italy aut International Journal of Colorectal Disease Springer-Verlag 5/2(1990-05-01), 79-81 0179-1958 5:2<79 1990 5 384 https://doi.org/10.1007/BF00298473 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00298473 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Campieri M. Institute of Clinical Medicine and Gastroenterology, University of Bologna, Italy aut NATIONALLICENCE 700 1- Gionchetti P. Institute of Clinical Medicine and Gastroenterology, University of Bologna, Italy aut NATIONALLICENCE 700 1- Belluzzi A. Institute of Clinical Medicine and Gastroenterology, University of Bologna, Italy aut NATIONALLICENCE 700 1- Brignola C. Institute of Clinical Medicine and Gastroenterology, University of Bologna, Italy aut NATIONALLICENCE 700 1- Tampieri M. Institute of Clinical Medicine and Gastroenterology, University of Bologna, Italy aut NATIONALLICENCE 700 1- Iannone P. Institute of Clinical Medicine and Gastroenterology, University of Bologna, Italy aut NATIONALLICENCE 700 1- Brunetti P. Giuliani Medical Department, Milano, Italy aut NATIONALLICENCE 700 1- Miglioli M. Institute of Clinical Medicine and Gastroenterology, University of Bologna, Italy aut NATIONALLICENCE 700 1- Barbara L. Institute of Clinical Medicine and Gastroenterology, University of Bologna, Italy aut NATIONALLICENCE 773 0- International Journal of Colorectal Disease Springer-Verlag 5/2(1990-05-01), 79-81 0179-1958 5:2<79 1990 5 384 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer