caa a22 4500 465763103 CHVBK 20180323111904.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02896926 doi (NATIONALLICENCE)springer-10.1007/BF02896926 Cerebral ischemia in gerbils: Postischemic administration of cyclohexyl adenosine and 8-sulfophenyl-theophylline [Elektronische Daten] [Dag von Lubitz, Paul Marangos] Adenosine agonists have now been shown by several laboratories to have profound neuroprotective effects when administered either pre-or postischemia. In an effort to determine whether these effects are centrally mediated, the effects of the non-brain-permeable aenosine receptor antagonist 8-sulfophenyl-theophylline (8-SPTH) on cyclohexyladenosine (CHA)-mediated protection was determined. Both survival and neurologic outcome were assessed in gerbils following 30 minutes of bilateral carotid occlusion. A dose of 2 mg/kg of CHA 5 minutes postreperfusion resulted in highly significant increases in survival relative to saline injected controls. Administration of doses of 8-SPTH sufficient to normalize the hypotension observed with CHA resulted in the same degree of postischemic protection. Similar results were obtained when neurologic status was evaluated. The results indicate that the neuroprotective effects of CHA are apparently centrally mediated. Birkhäuser, 1990 von Lubitz Dag Department of Biochemistry, Hahnemann University School of Medicine, 19102, Philadelphia, PA, USA aut Marangos Paul Gensia Pharmaceuticals, San Diego, California, USA aut Journal of Molecular Neuroscience Humana Press 2/1(1990-03-01), 53-59 0895-8696 2:1<53 1990 2 12031 https://doi.org/10.1007/BF02896926 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02896926 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- von Lubitz Dag Department of Biochemistry, Hahnemann University School of Medicine, 19102, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Marangos Paul Gensia Pharmaceuticals, San Diego, California, USA aut NATIONALLICENCE 773 0- Journal of Molecular Neuroscience Humana Press 2/1(1990-03-01), 53-59 0895-8696 2:1<53 1990 2 12031 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer