caa a22 4500 465763162 CHVBK 20180323111905.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF02896841 doi (NATIONALLICENCE)springer-10.1007/BF02896841 Identification of two nerve growth factor-induced polypeptides in PC12 cells [Elektronische Daten] [Mark Sussman, Elena Battenberg, Floyd Bloom, Velia Fowler] We have identified two nerve growth factor (NGF)-induced polypeptides (Mr 80,000 and 90,000) in PC12 cells that are heat stable and not sulfated. Indirect immunofluorescence localization of these polypeptides in NGF-treated PC12 cells reveals a punctate pattern concentrated in neurites. Immunoperoxidase staining of rat tissue shows that these polypeptides are found throughout the brain in selected subsets of neurons and are absent in the pituitary or adrenal medulla. Several of these characteristics are similar to a recently described NGF-induced secretory protein (VGF8a), which has sequence similarities to secretogranins. The property of NGF inducibility and the distribution of these polypeptides within rat tissues are both novel features for secretogranin proteins. Birkhäuser, 1990 Sussman Mark Department of Molecular Biology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Battenberg Elena Department of Neuropharmacology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Bloom Floyd Department of Neuropharmacology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Fowler Velia Department of Molecular Biology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Journal of Molecular Neuroscience Humana Press 2/3(1990-09-01), 163-174 0895-8696 2:3<163 1990 2 12031 https://doi.org/10.1007/BF02896841 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02896841 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sussman Mark Department of Molecular Biology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Battenberg Elena Department of Neuropharmacology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Bloom Floyd Department of Neuropharmacology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Fowler Velia Department of Molecular Biology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 773 0- Journal of Molecular Neuroscience Humana Press 2/3(1990-09-01), 163-174 0895-8696 2:3<163 1990 2 12031 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer