caa a22 4500 465763936 CHVBK 20180323111908.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF00914029 doi (NATIONALLICENCE)springer-10.1007/BF00914029 Chemotactic response of human monocytes to pentapeptide analog derived from immunodeficiency virus protein gp 120 [Elektronische Daten] [S. Spisani, R. Gavioli, A. Giuliani, T. Cavalletti, M. Marastoni, G. Balboni, S. Salvadori, R. Tomatis, S. Traniello] The octapeptide sequence of peptide T is contained within the envelope of HIV and seems to mediate the viral binding to CD4 expressing cells, including monocytes. The biological activity of the α-aminobutyric acid pentapeptide derived from the C-terminal sequence of peptide T, in which the polar side chain of threonine in position 4 is substituted by a hydrophilic group, is measured by the monocyte chemotaxis assay. The ehemotactic activity of human monocytes is assessed by determining the concentration at which the pentapeptide analog is maximally active and the effectiveness at that concentration, in comparison with peptide T and two shorter homologs, the pentapeptide and tetrapeptide. These experiments suggest that the synthetic analog is a potent ehemotactic factor active at picomolar concentrations and that it competes with peptide T for the monocyte binding site. Plenum Publishing Corporation, 1990 Spisani S. Istituto di Chimica Biologica, Italy aut Gavioli R. Istituto di Chimica Biologica, Italy aut Giuliani A. Istituto di Chimica Biologica, Italy aut Cavalletti T. Istituto di Chimica Biologica, Italy aut Marastoni M. Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Ferrara, Italy aut Balboni G. Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Ferrara, Italy aut Salvadori S. Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Ferrara, Italy aut Tomatis R. Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Ferrara, Italy aut Traniello S. Istituto di Chimica Biologica, Italy aut Inflammation Kluwer Academic Publishers-Plenum Publishers 14/1(1990-02-01), 55-60 0360-3997 14:1<55 1990 14 10753 https://doi.org/10.1007/BF00914029 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00914029 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Spisani S. Istituto di Chimica Biologica, Italy aut NATIONALLICENCE 700 1- Gavioli R. Istituto di Chimica Biologica, Italy aut NATIONALLICENCE 700 1- Giuliani A. Istituto di Chimica Biologica, Italy aut NATIONALLICENCE 700 1- Cavalletti T. Istituto di Chimica Biologica, Italy aut NATIONALLICENCE 700 1- Marastoni M. Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Ferrara, Italy aut NATIONALLICENCE 700 1- Balboni G. Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Ferrara, Italy aut NATIONALLICENCE 700 1- Salvadori S. Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Ferrara, Italy aut NATIONALLICENCE 700 1- Tomatis R. Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Ferrara, Italy aut NATIONALLICENCE 700 1- Traniello S. Istituto di Chimica Biologica, Italy aut NATIONALLICENCE 773 0- Inflammation Kluwer Academic Publishers-Plenum Publishers 14/1(1990-02-01), 55-60 0360-3997 14:1<55 1990 14 10753 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer