caa a22 4500 465763995 CHVBK 20180323111908.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF00914035 doi (NATIONALLICENCE)springer-10.1007/BF00914035 Studies on inflammatory response induced by Ehrlich tumor in mice peritoneal cavity [Elektronische Daten] [Denise Fecchio, Pierre Sirois, Momtchilo Russo, Sonia Jancar] In the present study we investigated the inflammatory response induced by the inoculation of Ehrlich tumor cells (EAT) into the peritoneal cavity of mice. It was found that after inoculation of 103 EAT cells, the number of peritoneal leukocytes remained unchanged till the sixth day. Subsequently, the number of cells increased as a consequence of tumor growth. EAT cells did not induce influx of PMN leukocytes till six days after tumor implantation, but a significant influx was observed on the tenth day. Inoculation of the tumor cells did not induce production of H2O2 by peritoneal cells at any time examined and induced low levels of macrophage spreading only until the third day after tumor implantation but not later on. The levels of thromboxane in the peritoneal cavity were not affected by the presence of the tumor, whereas prostaglandin E2 levels were significantly increased at all times examined. The biological significance of these results on the evolution and escape of the tumor from host defense mechanisms is under investigation. Plenum Publishing Corporation, 1990 Fecchio Denise Departamento de Imunologia Institute de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil aut Sirois Pierre Department of Pharmacology, University of Sherbrooke, Sherbrooke, Quebec, Canada aut Russo Momtchilo Departamento de Imunologia Institute de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil aut Jancar Sonia Departamento de Imunologia Institute de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil aut Inflammation Kluwer Academic Publishers-Plenum Publishers 14/1(1990-02-01), 125-132 0360-3997 14:1<125 1990 14 10753 https://doi.org/10.1007/BF00914035 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00914035 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fecchio Denise Departamento de Imunologia Institute de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Sirois Pierre Department of Pharmacology, University of Sherbrooke, Sherbrooke, Quebec, Canada aut NATIONALLICENCE 700 1- Russo Momtchilo Departamento de Imunologia Institute de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Jancar Sonia Departamento de Imunologia Institute de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil aut NATIONALLICENCE 773 0- Inflammation Kluwer Academic Publishers-Plenum Publishers 14/1(1990-02-01), 125-132 0360-3997 14:1<125 1990 14 10753 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer