caa a22 4500 46576407X CHVBK 20180323111908.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF00916374 doi (NATIONALLICENCE)springer-10.1007/BF00916374 Peptide opioids and morphine effects on inflammatory process [Elektronische Daten] [A. Mazzone, G. Ricevuti, D. Pasotti, A. Fioravanti, M. Marcoli, S. Lecchini, A. Notario, G. Frigo] Morphine was found to inhibit human granulocyte aggregation and ATP, thromboxane B2 (TxB2), and leukotriene B4 (LTB4) secretion during cell aggregation. None of the opioid peptides tested [(d-Ala2,d-Leu5)-enkephalin (DADL), (d-Ala2, N-Me-Phe4, Gly-ol5)-enkephalin (DAGO) ordynorphin 1-9 (Dyn 1-9)] was capable of mimicking morphine effects, while Dyn 1-9 per se induced TxB2 and LTB4 secretion from granulocytes. Morphine inhibition of both cell aggregation and ATP, but not of arachidonic acid metabolism product secretion, was prevented by naloxone. The naloxone-sensitive impairment by morphine of CD11b-CD18 complex surface expression observed could play a role in opioid inhibition of granulocyte activation. Plenum Publishing Corporation, 1990 Mazzone A. Department of Internal Medicine and Therapeutics Section of Medical Pathology and Section of Pharmacology, University of Pavia IRCCS San Matteo Hospital, P. le Golgi 2, 27100, Pavia, Italy aut Ricevuti G. Department of Internal Medicine and Therapeutics Section of Medical Pathology and Section of Pharmacology, University of Pavia IRCCS San Matteo Hospital, P. le Golgi 2, 27100, Pavia, Italy aut Pasotti D. Department of Internal Medicine and Therapeutics Section of Medical Pathology and Section of Pharmacology, University of Pavia IRCCS San Matteo Hospital, P. le Golgi 2, 27100, Pavia, Italy aut Fioravanti A. Department of Internal Medicine and Therapeutics Section of Medical Pathology and Section of Pharmacology, University of Pavia IRCCS San Matteo Hospital, P. le Golgi 2, 27100, Pavia, Italy aut Marcoli M. Department of Internal Medicine and Therapeutics Section of Medical Pathology and Section of Pharmacology, University of Pavia IRCCS San Matteo Hospital, P. le Golgi 2, 27100, Pavia, Italy aut Lecchini S. Department of Internal Medicine and Therapeutics Section of Medical Pathology and Section of Pharmacology, University of Pavia IRCCS San Matteo Hospital, P. le Golgi 2, 27100, Pavia, Italy aut Notario A. Department of Internal Medicine and Therapeutics Section of Medical Pathology and Section of Pharmacology, University of Pavia IRCCS San Matteo Hospital, P. le Golgi 2, 27100, Pavia, Italy aut Frigo G. Department of Internal Medicine and Therapeutics Section of Medical Pathology and Section of Pharmacology, University of Pavia IRCCS San Matteo Hospital, P. le Golgi 2, 27100, Pavia, Italy aut Inflammation Kluwer Academic Publishers-Plenum Publishers 14/6(1990-12-01), 717-726 0360-3997 14:6<717 1990 14 10753 https://doi.org/10.1007/BF00916374 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00916374 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mazzone A. Department of Internal Medicine and Therapeutics Section of Medical Pathology and Section of Pharmacology, University of Pavia IRCCS San Matteo Hospital, P. le Golgi 2, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Ricevuti G. Department of Internal Medicine and Therapeutics Section of Medical Pathology and Section of Pharmacology, University of Pavia IRCCS San Matteo Hospital, P. le Golgi 2, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Pasotti D. Department of Internal Medicine and Therapeutics Section of Medical Pathology and Section of Pharmacology, University of Pavia IRCCS San Matteo Hospital, P. le Golgi 2, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Fioravanti A. Department of Internal Medicine and Therapeutics Section of Medical Pathology and Section of Pharmacology, University of Pavia IRCCS San Matteo Hospital, P. le Golgi 2, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Marcoli M. Department of Internal Medicine and Therapeutics Section of Medical Pathology and Section of Pharmacology, University of Pavia IRCCS San Matteo Hospital, P. le Golgi 2, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Lecchini S. Department of Internal Medicine and Therapeutics Section of Medical Pathology and Section of Pharmacology, University of Pavia IRCCS San Matteo Hospital, P. le Golgi 2, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Notario A. Department of Internal Medicine and Therapeutics Section of Medical Pathology and Section of Pharmacology, University of Pavia IRCCS San Matteo Hospital, P. le Golgi 2, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Frigo G. Department of Internal Medicine and Therapeutics Section of Medical Pathology and Section of Pharmacology, University of Pavia IRCCS San Matteo Hospital, P. le Golgi 2, 27100, Pavia, Italy aut NATIONALLICENCE 773 0- Inflammation Kluwer Academic Publishers-Plenum Publishers 14/6(1990-12-01), 717-726 0360-3997 14:6<717 1990 14 10753 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer