caa a22 4500 465764118 CHVBK 20180323111908.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF00915815 doi (NATIONALLICENCE)springer-10.1007/BF00915815 Prevalence of tri- and tetraantennary glycans of human α 1-acid glycoprotein in release of macrophage inhibitor of interleukin-1 activity [Elektronische Daten] [Phuong Bories, Jeanne Feger, NaÏma Benbernou, Jean-Denis Rouzeau, Jean Agneray, Geneviève Durand] Based on the affinity for concanavalin A (Con A), human α1-acid glycoprotein (AGP) can be separated by chromatography on Con A-Sepharose gel into three variants: Con A unreactive AGP, Con A weakly reactive AGP, and Con A strongly reactive AGP. When exposed to native AGP or to its glycan variants, murine peritoneal macrophages released a factor that inhibited the interleukin-1 (IL-1) proliferative activity as measured in terms of the thymocyte comitogenic assay. Con A unreactive AGP, which contains tri- and tetraantennary glycans and no biantennae, proved to be more effective than Con A weakly and Con A strongly reactive variants, which contain one and two diantennary glycans, respectively. The inhibitory effect was not a function of the negative charge related to the sialyl residues and was not mediated by the maanosyl-fucosyl receptor. Plenum Publishing Corporation, 1990 Bories Phuong Laboratoire de Biochimie, Université Paris-Sud, 5 rue J. B. Clément, 92296, Châtenay-Malabry, France aut Feger Jeanne Laboratoire de Biochimie, Université Paris-Sud, 5 rue J. B. Clément, 92296, Châtenay-Malabry, France aut Benbernou NaÏma Laboratoire de Biochimie, Université Paris-Sud, 5 rue J. B. Clément, 92296, Châtenay-Malabry, France aut Rouzeau Jean-Denis Laboratoire de Biochimie, Université Paris-Sud, 5 rue J. B. Clément, 92296, Châtenay-Malabry, France aut Agneray Jean Laboratoire de Biochimie, Université Paris-Sud, 5 rue J. B. Clément, 92296, Châtenay-Malabry, France aut Durand Geneviève Laboratoire de Biochimie, Université Paris-Sud, 5 rue J. B. Clément, 92296, Châtenay-Malabry, France aut Inflammation Kluwer Academic Publishers-Plenum Publishers 14/3(1990-06-01), 315-323 0360-3997 14:3<315 1990 14 10753 https://doi.org/10.1007/BF00915815 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00915815 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bories Phuong Laboratoire de Biochimie, Université Paris-Sud, 5 rue J. B. Clément, 92296, Châtenay-Malabry, France aut NATIONALLICENCE 700 1- Feger Jeanne Laboratoire de Biochimie, Université Paris-Sud, 5 rue J. B. Clément, 92296, Châtenay-Malabry, France aut NATIONALLICENCE 700 1- Benbernou NaÏma Laboratoire de Biochimie, Université Paris-Sud, 5 rue J. B. Clément, 92296, Châtenay-Malabry, France aut NATIONALLICENCE 700 1- Rouzeau Jean-Denis Laboratoire de Biochimie, Université Paris-Sud, 5 rue J. B. Clément, 92296, Châtenay-Malabry, France aut NATIONALLICENCE 700 1- Agneray Jean Laboratoire de Biochimie, Université Paris-Sud, 5 rue J. B. Clément, 92296, Châtenay-Malabry, France aut NATIONALLICENCE 700 1- Durand Geneviève Laboratoire de Biochimie, Université Paris-Sud, 5 rue J. B. Clément, 92296, Châtenay-Malabry, France aut NATIONALLICENCE 773 0- Inflammation Kluwer Academic Publishers-Plenum Publishers 14/3(1990-06-01), 315-323 0360-3997 14:3<315 1990 14 10753 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer