caa a22 4500 465764169 CHVBK 20180323111908.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF00915816 doi (NATIONALLICENCE)springer-10.1007/BF00915816 Ocular inflammatory effects of intravitreally injected tumor necrosis factor-alpha and endotoxin [Elektronische Daten] [Lloyd Fleisher, Jenny Ferrell, M. McGahan] Intravitreal injection of human recombinant tumor necrosis factor-alpha (TNF) induced inflammation in the rabbit eye characterized by dilation of blood vessels in the iris, disruption of the blood-ocular barriers, infiltration of inflammatory cells into the anterior chamber, and accumulation of prostaglandin E in intraocular fluids. Inflammation first appeared on day 1, increased on day 2, and remained elevated on day 7. The inflammatory eell infiltrate in the anterior segment of the eye was largely monocytic on days 1 and 2; by day 7 large numbers of lymphocytes were also present. TNF-induced ocular inflammation therefore differed from that reported for intravitreally injected endotoxin in terms of time course and the types of inflammatory cells in the aqueous humor. In a series of experiments in which combinations of TNF and endotoxin were used, intravitreal injection of TNF, 24 h after a low dose ofEscherichia coli endotoxin, produced no more inflammation than that produced by TNF following an injection of endotoxin vehicle. However, if TNF was injected 24 h before endotoxin, the resulting inflammation was greater than that observed in animals given TNF followed by endotoxin vehicle. Plenum Publishing Corporation, 1990 Fleisher Lloyd Department of Anatomy, Physiological Sciences and Radiology College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, 27606, Raleigh, North Carolina aut Ferrell Jenny Department of Anatomy, Physiological Sciences and Radiology College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, 27606, Raleigh, North Carolina aut McGahan M. Department of Anatomy, Physiological Sciences and Radiology College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, 27606, Raleigh, North Carolina aut Inflammation Kluwer Academic Publishers-Plenum Publishers 14/3(1990-06-01), 325-335 0360-3997 14:3<325 1990 14 10753 https://doi.org/10.1007/BF00915816 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00915816 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fleisher Lloyd Department of Anatomy, Physiological Sciences and Radiology College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, 27606, Raleigh, North Carolina aut NATIONALLICENCE 700 1- Ferrell Jenny Department of Anatomy, Physiological Sciences and Radiology College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, 27606, Raleigh, North Carolina aut NATIONALLICENCE 700 1- McGahan M. Department of Anatomy, Physiological Sciences and Radiology College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, 27606, Raleigh, North Carolina aut NATIONALLICENCE 773 0- Inflammation Kluwer Academic Publishers-Plenum Publishers 14/3(1990-06-01), 325-335 0360-3997 14:3<325 1990 14 10753 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer