caa a22 4500 465764185 CHVBK 20180323111909.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF00915812 doi (NATIONALLICENCE)springer-10.1007/BF00915812 α 2-Macroglobulin and fibrinogen modulate inflammatory edema in man [Elektronische Daten] [J. Van Gool, H. Van Vugt, E. De Bont] Animal experiments suggest that the response of acute-phase proteins (APPs) modulates the inflammatory reaction following tissue injury. To study this in man we investigated the relation between a number of APPs, including fibrinogen and α2-macroglobulin, and the inflammatory edema induced by a primary immunization against cholera, typhoid, and yellow fever. Vaccination induces a significant APP response; however, only α2-macroglobulin and fibrinogen were of importance to the amount of edema, measured 24 h after vaccination. High plasma levels of α2-macroglobulin strongly inhibit the amount of edema, whereas a high level of fibrinogen proved to be a stimulating factor. This holds both for the basal prevaccination levels and the postvaccination levels. The normal variation of the plasma concentration of these proteins in healthy subjects seems to be a determining factor to the amount of edema in this kind of injury. Plenum Publishing Corporation, 1990 Van Gool J. Laboratory of Experimental Medicine, University of Amsterdam Academic Medical Center, Meibergdreef 9, 1105, AZ Amsterdam, The Netherlands aut Van Vugt H. Laboratory of Experimental Medicine, University of Amsterdam Academic Medical Center, Meibergdreef 9, 1105, AZ Amsterdam, The Netherlands aut De Bont E. Laboratory of Experimental Medicine, University of Amsterdam Academic Medical Center, Meibergdreef 9, 1105, AZ Amsterdam, The Netherlands aut Inflammation Kluwer Academic Publishers-Plenum Publishers 14/3(1990-06-01), 275-283 0360-3997 14:3<275 1990 14 10753 https://doi.org/10.1007/BF00915812 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00915812 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Van Gool J. Laboratory of Experimental Medicine, University of Amsterdam Academic Medical Center, Meibergdreef 9, 1105, AZ Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Van Vugt H. Laboratory of Experimental Medicine, University of Amsterdam Academic Medical Center, Meibergdreef 9, 1105, AZ Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- De Bont E. Laboratory of Experimental Medicine, University of Amsterdam Academic Medical Center, Meibergdreef 9, 1105, AZ Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- Inflammation Kluwer Academic Publishers-Plenum Publishers 14/3(1990-06-01), 275-283 0360-3997 14:3<275 1990 14 10753 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer