caa a22 4500 465764207 CHVBK 20180323111909.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF00915808 doi (NATIONALLICENCE)springer-10.1007/BF00915808 Production of arachidonic acid metabolites by caprine alveolar macrophages [Elektronische Daten] [Mark Englen, Stephen Taylor, William Laegreid, Ronald Silflow, Keith Banks, R. Leid] The in vitro release of arachidonic acid (AA) metabolites from caprine alveolar macrophages (CAM) stimulated with the calcium ionophore A23187 or opsonized zymosan was examined. Leukotriene B4 [5(S),12(R)-6,14-cis-8,10-trans-dihydroxyeicosatetraenoic acid] was the major AA metabolite elicited with either agonist; smaller amounts of 12- and 5-mono-hydroxyeicosatetraenoic acid (HETE), and 12-hydroxyheptadecatrienoic acid (HHT) were also detected. Zymosan stimulation also caused the release of very small quantities of prostaglandins E2 and F2α, and thromboxane B2. Our report is the first to describe arachidonic acid metabolism in CAM. Plenum Publishing Corporation, 1990 Englen Mark Laboratory of Molecular and Cellular Inflammation Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, 99164-7040, Pullman, Washington aut Taylor Stephen Ligand Pharmaceuticals, 9393 Towne Center Drive, 92121, San Diego, California aut Laegreid William Plum Island Animal Disease Center, NAA/ARS/USDA, 11944, Greenport, New York aut Silflow Ronald Laboratory of Molecular and Cellular Inflammation Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, 99164-7040, Pullman, Washington aut Banks Keith Laboratory of Molecular and Cellular Inflammation Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, 99164-7040, Pullman, Washington aut Leid R. Laboratory of Molecular and Cellular Inflammation Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, 99164-7040, Pullman, Washington aut Inflammation Kluwer Academic Publishers-Plenum Publishers 14/3(1990-06-01), 239-245 0360-3997 14:3<239 1990 14 10753 https://doi.org/10.1007/BF00915808 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00915808 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Englen Mark Laboratory of Molecular and Cellular Inflammation Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, 99164-7040, Pullman, Washington aut NATIONALLICENCE 700 1- Taylor Stephen Ligand Pharmaceuticals, 9393 Towne Center Drive, 92121, San Diego, California aut NATIONALLICENCE 700 1- Laegreid William Plum Island Animal Disease Center, NAA/ARS/USDA, 11944, Greenport, New York aut NATIONALLICENCE 700 1- Silflow Ronald Laboratory of Molecular and Cellular Inflammation Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, 99164-7040, Pullman, Washington aut NATIONALLICENCE 700 1- Banks Keith Laboratory of Molecular and Cellular Inflammation Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, 99164-7040, Pullman, Washington aut NATIONALLICENCE 700 1- Leid R. Laboratory of Molecular and Cellular Inflammation Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, 99164-7040, Pullman, Washington aut NATIONALLICENCE 773 0- Inflammation Kluwer Academic Publishers-Plenum Publishers 14/3(1990-06-01), 239-245 0360-3997 14:3<239 1990 14 10753 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer