caa a22 4500 465764231 CHVBK 20180323111909.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00914097 doi (NATIONALLICENCE)springer-10.1007/BF00914097 Auranofin-induced suppression of autoimmune antibody production and inflammation in genetically autoimmune-prone mice [Elektronische Daten] [Herman Friedman, Steven Specter, Thomas Klein, Catherine Newton, Melodie Rivenbark, David Rowlands, Donald Walz] The gold compound auranofin and lobenzarit (CCA) were compared in regard to effects on development of an autoimmune-like disease in MRL/1 mice, which normally develop elevated levels of serum anti-DNA antibodies and rheumatoid factor as well as joint lesions similar to those seen in patients with rheumatoid arthritis. MRL/1 mice, which are genetically prone to development of autoimmune disease, were given auranofin or lobenzarit by gavage for 15 weeks, starting at 6 weeks of age. Mice were examined periodically for immunological abnormalities as well as histologie changes in articular joints. The auranofin-treated mice showed marked diminution in development of anti-DNA antibodies and serum rheumatoid factor as compared to control animals. Although higher than in the auranofin-treated animals, CCA-treated mice also had lower levels of serum autoantibodies than those seen in the control animals. Examination of limb joints for histopathologic changes indicated that the auranofin-treated animals developed only the slightest evidence of lesions as compared to control animals. CCA-treated mice also had a lessening of lesion development compared to control animals, but lesions were more developed than in auranofin-treated mice. This study indicates that auranofin is more effective than CCA in diminishing development of autoimmunity in MRL/1 mice. Plenum Publishing Corporation, 1990 Friedman Herman Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, Florida aut Specter Steven Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, Florida aut Klein Thomas Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, Florida aut Newton Catherine Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, Florida aut Rivenbark Melodie Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, Florida aut Rowlands David Department of Pathology and Laboratory Medicine, University of South Florida College of Medicine, Tampa, Florida aut Walz Donald Division of Pharmacology, Smith Kline and French Research Laboratories, Philadelphia, Pennsylvania aut Inflammation Kluwer Academic Publishers-Plenum Publishers 14/4(1990-08-01), 463-470 0360-3997 14:4<463 1990 14 10753 https://doi.org/10.1007/BF00914097 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00914097 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Friedman Herman Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, Florida aut NATIONALLICENCE 700 1- Specter Steven Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, Florida aut NATIONALLICENCE 700 1- Klein Thomas Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, Florida aut NATIONALLICENCE 700 1- Newton Catherine Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, Florida aut NATIONALLICENCE 700 1- Rivenbark Melodie Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, Florida aut NATIONALLICENCE 700 1- Rowlands David Department of Pathology and Laboratory Medicine, University of South Florida College of Medicine, Tampa, Florida aut NATIONALLICENCE 700 1- Walz Donald Division of Pharmacology, Smith Kline and French Research Laboratories, Philadelphia, Pennsylvania aut NATIONALLICENCE 773 0- Inflammation Kluwer Academic Publishers-Plenum Publishers 14/4(1990-08-01), 463-470 0360-3997 14:4<463 1990 14 10753 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer