caa a22 4500 465764282 CHVBK 20180323111909.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00914091 doi (NATIONALLICENCE)springer-10.1007/BF00914091 Production of arachidonic and linoleic acid metabolites by guinea pig tracheal epithelial cells [Elektronische Daten] [M. Oosthuizen, F. Engels, B. van Esch, P. Henricks, F. Nijkamp] Pulmonary epithelial cells may be responsible for regulating airway smooth muscle function, in part by release of fatty acid-derived mediators. Incubation of isolated guinea pig tracheal epithelial cells with radiolabeled arachidonic acid (AA) leads to the production of 5- and 15-hydroxyeicosatetraenoic acid (5- and 15-HETE) and smaller amounts of leukotriene (LT) B4 and C4 and 12-hydroxyheptadecatrienoic acid (HHT). Epithelial cells also are able to release linoleic acid (LA) metabolites. Incubation with radiolabeled linoleic acid leads to the formation of 9- and 13-hydroxyoctadecadienoic acid (9- and 13-HODE). The biological significance of these mediators produced by epithelial cells is discussed. Plenum Publishing Corporation, 1990 Oosthuizen M. Department of Pharmacology, Faculty of Pharmacy, State University of Utrecht, Catharijnesingel 60, 3511, GH Utrecht, The Netherlands aut Engels F. Department of Pharmacology, Faculty of Pharmacy, State University of Utrecht, Catharijnesingel 60, 3511, GH Utrecht, The Netherlands aut van Esch B. Department of Pharmacology, Faculty of Pharmacy, State University of Utrecht, Catharijnesingel 60, 3511, GH Utrecht, The Netherlands aut Henricks P. Department of Pharmacology, Faculty of Pharmacy, State University of Utrecht, Catharijnesingel 60, 3511, GH Utrecht, The Netherlands aut Nijkamp F. Department of Pharmacology, Faculty of Pharmacy, State University of Utrecht, Catharijnesingel 60, 3511, GH Utrecht, The Netherlands aut Inflammation Kluwer Academic Publishers-Plenum Publishers 14/4(1990-08-01), 401-408 0360-3997 14:4<401 1990 14 10753 https://doi.org/10.1007/BF00914091 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00914091 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Oosthuizen M. Department of Pharmacology, Faculty of Pharmacy, State University of Utrecht, Catharijnesingel 60, 3511, GH Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Engels F. Department of Pharmacology, Faculty of Pharmacy, State University of Utrecht, Catharijnesingel 60, 3511, GH Utrecht, The Netherlands aut NATIONALLICENCE 700 1- van Esch B. Department of Pharmacology, Faculty of Pharmacy, State University of Utrecht, Catharijnesingel 60, 3511, GH Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Henricks P. Department of Pharmacology, Faculty of Pharmacy, State University of Utrecht, Catharijnesingel 60, 3511, GH Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Nijkamp F. Department of Pharmacology, Faculty of Pharmacy, State University of Utrecht, Catharijnesingel 60, 3511, GH Utrecht, The Netherlands aut NATIONALLICENCE 773 0- Inflammation Kluwer Academic Publishers-Plenum Publishers 14/4(1990-08-01), 401-408 0360-3997 14:4<401 1990 14 10753 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer