caa a22 4500 46576438X CHVBK 20180323111909.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF00914276 doi (NATIONALLICENCE)springer-10.1007/BF00914276 Characterization of leukocyte chemotactic activity of bacteriocin from Streptococcus mutans Rm-10 [Elektronische Daten] [Yoshio Tsukamoto, Sachiko Fukutani, Yasuyuki Takayama, Hisanori Fukushima, Hirosuke Sagawa, Masakazu Mori] Bacteriocins have several biological activities in addition to their antibacterial effect. We investigated the chemotactic properties and mode of action of purified streptococcal bacteriocin. Bacteriocin purified from a culture supernatant ofStreptococcus mutans (S. mutans) Rm-10 induced chemotaxis of human polymorphonuclear leukocytes and monocytes. Following purification, leukocyte migration appeared in one bacteriocin fraction, and this migration was dependent on the concentration gradient in dilution ranges from 1/960 to 1/15. Chemotactic activity of the bacteriocin was heat labile and trypsin sensitive. Moreover, preincubation of bacteriocin with varying dilutions of its antiserum prepared in rabbits resulted in a significant loss of the chemotactic activity. Plenum Publishing Corporation, 1990 Tsukamoto Yoshio Department of Pharmacology, Osaka Dental University, 5-31, Otemae 1-chome Chuo-ku, 540, Osaka, Japan aut Fukutani Sachiko Department of Pharmacology, Osaka Dental University, 5-31, Otemae 1-chome Chuo-ku, 540, Osaka, Japan aut Takayama Yasuyuki Department of Pharmacology, Osaka Dental University, 5-31, Otemae 1-chome Chuo-ku, 540, Osaka, Japan aut Fukushima Hisanori Department of Bacteriology, Osaka Dental University, 5-31, Otemae 1-chome Chuo-ku, 540, Osaka, Japan aut Sagawa Hirosuke Department of Bacteriology, Osaka Dental University, 5-31, Otemae 1-chome Chuo-ku, 540, Osaka, Japan aut Mori Masakazu Department of Pharmacology, Osaka Dental University, 5-31, Otemae 1-chome Chuo-ku, 540, Osaka, Japan aut Inflammation Kluwer Academic Publishers-Plenum Publishers 14/5(1990-10-01), 561-569 0360-3997 14:5<561 1990 14 10753 https://doi.org/10.1007/BF00914276 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00914276 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tsukamoto Yoshio Department of Pharmacology, Osaka Dental University, 5-31, Otemae 1-chome Chuo-ku, 540, Osaka, Japan aut NATIONALLICENCE 700 1- Fukutani Sachiko Department of Pharmacology, Osaka Dental University, 5-31, Otemae 1-chome Chuo-ku, 540, Osaka, Japan aut NATIONALLICENCE 700 1- Takayama Yasuyuki Department of Pharmacology, Osaka Dental University, 5-31, Otemae 1-chome Chuo-ku, 540, Osaka, Japan aut NATIONALLICENCE 700 1- Fukushima Hisanori Department of Bacteriology, Osaka Dental University, 5-31, Otemae 1-chome Chuo-ku, 540, Osaka, Japan aut NATIONALLICENCE 700 1- Sagawa Hirosuke Department of Bacteriology, Osaka Dental University, 5-31, Otemae 1-chome Chuo-ku, 540, Osaka, Japan aut NATIONALLICENCE 700 1- Mori Masakazu Department of Pharmacology, Osaka Dental University, 5-31, Otemae 1-chome Chuo-ku, 540, Osaka, Japan aut NATIONALLICENCE 773 0- Inflammation Kluwer Academic Publishers-Plenum Publishers 14/5(1990-10-01), 561-569 0360-3997 14:5<561 1990 14 10753 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer