caa a22 4500 465764452 CHVBK 20180323111909.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00917457 doi (NATIONALLICENCE)springer-10.1007/BF00917457 Comparison of abilities of recombinant interleukin-1α and - β and noninflammatory IL-1 β fragment 163-171 to upregulate C3b receptors (CR1) on human neutrophils and to enhance their phagocytic capacity [Elektronische Daten] [James Ogle, J. Noel, Ambikaipakan Balasurbramaniam, R. Sramkoski, Cora Ogle, J. Alexander] Both recombinant IL-1α and -β caused an upregulation of C3b receptors (CR1) on human neutrophils and caused a receptor-mediated enhancement of phagocytosis of C3b·IgG-coated microspheres by these leukocytes. Theα andβ forms of the recombinant cytokine were of comparable potency regarding CR1 upregulation, although both generally had less than 25% of the potency of FMLP in this respect. Recombinant IL-1β was slightly more potent than theα form of the cytokine regarding phagocytosis of opsonized microspheres and, again, both forms were less potent than FMLP in causing an enhancement of phagocytosis by neutrophils. The synthetic noninflammatory immunostimulatory nonapeptide corresponding to residues 163-171 of IL-1β was completely inert with respect to upregulation of CR1 on neutrophils and the enhancement of phagocytosis by these cells. Thus this domain in the intact IL-1β molecule apparently is not involved in CR1 upregulation and the ensuing enhancement in phagocytosis by neutrophils, although it is apparently important in the immunostimulatory activity regarding the proliferation of lymphocytes. Plenum Publishing Corporation, 1990 Ogle James Departments of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati Medical Center, 231 Bethesda Avenue, 45267, Cincinnati, Ohio aut Noel J. Cincinnati Unit, The Shriners Burns Institute, USA aut Balasurbramaniam Ambikaipakan Department of Surgery, University of Cincinnati Medical Center, 231 Bethesda Avenue, 45267, Cincinnati, Ohio aut Sramkoski R. Cincinnati Unit, The Shriners Burns Institute, USA aut Ogle Cora Department of Surgery, University of Cincinnati Medical Center, 231 Bethesda Avenue, 45267, Cincinnati, Ohio aut Alexander J. Department of Surgery, University of Cincinnati Medical Center, 231 Bethesda Avenue, 45267, Cincinnati, Ohio aut Inflammation Kluwer Academic Publishers-Plenum Publishers 14/2(1990-04-01), 185-194 0360-3997 14:2<185 1990 14 10753 https://doi.org/10.1007/BF00917457 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00917457 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ogle James Departments of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati Medical Center, 231 Bethesda Avenue, 45267, Cincinnati, Ohio aut NATIONALLICENCE 700 1- Noel J. Cincinnati Unit, The Shriners Burns Institute, USA aut NATIONALLICENCE 700 1- Balasurbramaniam Ambikaipakan Department of Surgery, University of Cincinnati Medical Center, 231 Bethesda Avenue, 45267, Cincinnati, Ohio aut NATIONALLICENCE 700 1- Sramkoski R. Cincinnati Unit, The Shriners Burns Institute, USA aut NATIONALLICENCE 700 1- Ogle Cora Department of Surgery, University of Cincinnati Medical Center, 231 Bethesda Avenue, 45267, Cincinnati, Ohio aut NATIONALLICENCE 700 1- Alexander J. Department of Surgery, University of Cincinnati Medical Center, 231 Bethesda Avenue, 45267, Cincinnati, Ohio aut NATIONALLICENCE 773 0- Inflammation Kluwer Academic Publishers-Plenum Publishers 14/2(1990-04-01), 185-194 0360-3997 14:2<185 1990 14 10753 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer