caa a22 4500 465764479 CHVBK 20180323111909.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00917458 doi (NATIONALLICENCE)springer-10.1007/BF00917458 Remarkable elevation of leukotriene B4 in rat skin after induction of UV photodermatitis [Elektronische Daten] [Hidemitsu Nakaguma, Hitoshi Takahashi] Leukotriene B4 in the skin was remarkably elevated in the rat, but not in the guinea pig or the mouse 48 h after UV-B irradiation. These results were consistent with interspecies difference of PMN infiltration caused by UV-B irradiation. LTB4 in the rat skin was determined by both high-performance liquid chromatography and radioimmunoassay. LTB4 in the rat skin started to increase 24 h after irradiation and became about 65-fold higher in the irradiated site than in the nonirradiated site at the end of 48 h. This elevation was strongly inhibited by topical application of two 5-lipoxygenase inhibitors, AA-861 and piriprost, although the inflammatory reaction or infiltration of polymorphonuclear leukocytes was not much improved. Plenum Publishing Corporation, 1990 Nakaguma Hidemitsu Department of Pharmacology Institute for Medical Immunology, Kumamoto University Medical School, 860, Kumamoto-city, Japan aut Takahashi Hitoshi Department of Pharmacology Institute for Medical Immunology, Kumamoto University Medical School, 860, Kumamoto-city, Japan aut Inflammation Kluwer Academic Publishers-Plenum Publishers 14/2(1990-04-01), 195-203 0360-3997 14:2<195 1990 14 10753 https://doi.org/10.1007/BF00917458 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00917458 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nakaguma Hidemitsu Department of Pharmacology Institute for Medical Immunology, Kumamoto University Medical School, 860, Kumamoto-city, Japan aut NATIONALLICENCE 700 1- Takahashi Hitoshi Department of Pharmacology Institute for Medical Immunology, Kumamoto University Medical School, 860, Kumamoto-city, Japan aut NATIONALLICENCE 773 0- Inflammation Kluwer Academic Publishers-Plenum Publishers 14/2(1990-04-01), 195-203 0360-3997 14:2<195 1990 14 10753 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer