caa a22 4500 465764495 CHVBK 20180323111910.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00917459 doi (NATIONALLICENCE)springer-10.1007/BF00917459 Talc granulomatosis in the rat [Elektronische Daten] Involvement of bone in the acute-phase response [Ana Marušić, Ksenija Kos, Ana Stavljenić, Slobodan Vukičević] We investigated the dynamics of the acute-phase response (APR) and osteoblast trabecular surface in rats with subcutaneous inflammation provoked by magnesium silicate (talc). The first visible indicator of the APR was a rapid and profound hypozincemia, paralleled by a decrease in metaphyseal trabecular surfaces covered with osteoblasts in long bones. Both the intensity of serum APR and the decrease in osteoblast trabecular surface were directly proportional to the number of granulomas. Alterations in bone metabolism were specific for the inflammation, whereas mild hypozincemia and decrease in mononuclear and increase in polymorphonuclear peripheral white blood cell fractions developed in animals pair-fed with rats bearing two or four granulomas. Rats with talc granulomatosis had high serum ACTH and corticosterone levels, but neither adrenalectomy nor high doses of hydrocortisone could revert bone alterations in talc-injected animals. Glucocorticoids were necessary for the development of hypozincemia and hypercupremia seen in talc granulomatosis, as well as for normal bone metabolism. Inhibition of prostaglandin synthesis had no effect on bone alterations and serum APR in rats bearing talc-induced granulomas. We conclude that the decrease in bone formation constitutes an important aspect of the host acute-phase response in a rat model of talc granulomatosis. Plenum Publishing Corporation, 1990 Marušić Ana Departments of Anatomy and Biochemistry School of Medicine, University of Zagreb, Zagreb, Yugoslavia aut Kos Ksenija Departments of Anatomy and Biochemistry School of Medicine, University of Zagreb, Zagreb, Yugoslavia aut Stavljenić Ana Departments of Anatomy and Biochemistry School of Medicine, University of Zagreb, Zagreb, Yugoslavia aut Vukičević Slobodan Departments of Anatomy and Biochemistry School of Medicine, University of Zagreb, Zagreb, Yugoslavia aut Inflammation Kluwer Academic Publishers-Plenum Publishers 14/2(1990-04-01), 205-216 0360-3997 14:2<205 1990 14 10753 https://doi.org/10.1007/BF00917459 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00917459 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Marušić Ana Departments of Anatomy and Biochemistry School of Medicine, University of Zagreb, Zagreb, Yugoslavia aut NATIONALLICENCE 700 1- Kos Ksenija Departments of Anatomy and Biochemistry School of Medicine, University of Zagreb, Zagreb, Yugoslavia aut NATIONALLICENCE 700 1- Stavljenić Ana Departments of Anatomy and Biochemistry School of Medicine, University of Zagreb, Zagreb, Yugoslavia aut NATIONALLICENCE 700 1- Vukičević Slobodan Departments of Anatomy and Biochemistry School of Medicine, University of Zagreb, Zagreb, Yugoslavia aut NATIONALLICENCE 773 0- Inflammation Kluwer Academic Publishers-Plenum Publishers 14/2(1990-04-01), 205-216 0360-3997 14:2<205 1990 14 10753 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer