caa a22 4500 465764819 CHVBK 20180323111910.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00155593 doi (NATIONALLICENCE)springer-10.1007/BF00155593 Combination chemotherapy with cisplatin and nifedipine: synergistic antitumor effects against a cisplatin-resistant subline of the B16 amelanotic melanoma [Elektronische Daten] [James Onoda, Kevin Nelson, Sandra Pilarski, Nancy White, Oxana Mihu, Kenneth Honn] Cisplatin has become one of the most commonly prescribed cytotoxic chemotherapeutic agents. Unfortunately, the cure rate is low due to the development or outgrowth of cisplatin-resistant cells which repopulate tumors, resulting in patient death. We reported previously that the calcium channel blocker nifedipine enhances the antitumour actions of cisplatin (cis-diamminedichloroplatinum (II)) against murine tumors which are inherently cisplatin-sensitive (B16a) or inherently cisplatin-resistant (ML). We have developed an induced cisplatin-resistant tumor variant (B16a-Pt) that is 30 times more resistant to cisplatin than its cisplatin-sensitive parent line. In short-term studies, we report that nifedipine significantly enhanced the cytotoxicity of cisplatin against primary B16a-Pt tumors and their spontaneous pulmonary metastases. In long term studies, we report that combination therapy with nifedipine and cisplatin results in significantly enhanced survival. Taylor & Francis Ltd, 1990 Onoda James Department of Radiation Oncology, Wayne State University and the Gershenson Radiation Oncology Center, Harper/Grace Hospitals, 48201, Detroit, Michigan, U.S.A. aut Nelson Kevin Department of Radiation Oncology, Wayne State University and the Gershenson Radiation Oncology Center, Harper/Grace Hospitals, 48201, Detroit, Michigan, U.S.A. aut Pilarski Sandra Department of Radiation Oncology, Wayne State University and the Gershenson Radiation Oncology Center, Harper/Grace Hospitals, 48201, Detroit, Michigan, U.S.A. aut White Nancy Department of Radiation Oncology, Wayne State University and the Gershenson Radiation Oncology Center, Harper/Grace Hospitals, 48201, Detroit, Michigan, U.S.A. aut Mihu Oxana Department of Radiation Oncology, Wayne State University and the Gershenson Radiation Oncology Center, Harper/Grace Hospitals, 48201, Detroit, Michigan, U.S.A. aut Honn Kenneth Department of Radiation Oncology, Wayne State University and the Gershenson Radiation Oncology Center, Harper/Grace Hospitals, 48201, Detroit, Michigan, U.S.A. aut Clinical & Experimental Metastasis Kluwer Academic Publishers 8/1(1990-01-01), 59-73 0262-0898 8:1<59 1990 8 10585 https://doi.org/10.1007/BF00155593 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00155593 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Onoda James Department of Radiation Oncology, Wayne State University and the Gershenson Radiation Oncology Center, Harper/Grace Hospitals, 48201, Detroit, Michigan, U.S.A aut NATIONALLICENCE 700 1- Nelson Kevin Department of Radiation Oncology, Wayne State University and the Gershenson Radiation Oncology Center, Harper/Grace Hospitals, 48201, Detroit, Michigan, U.S.A aut NATIONALLICENCE 700 1- Pilarski Sandra Department of Radiation Oncology, Wayne State University and the Gershenson Radiation Oncology Center, Harper/Grace Hospitals, 48201, Detroit, Michigan, U.S.A aut NATIONALLICENCE 700 1- White Nancy Department of Radiation Oncology, Wayne State University and the Gershenson Radiation Oncology Center, Harper/Grace Hospitals, 48201, Detroit, Michigan, U.S.A aut NATIONALLICENCE 700 1- Mihu Oxana Department of Radiation Oncology, Wayne State University and the Gershenson Radiation Oncology Center, Harper/Grace Hospitals, 48201, Detroit, Michigan, U.S.A aut NATIONALLICENCE 700 1- Honn Kenneth Department of Radiation Oncology, Wayne State University and the Gershenson Radiation Oncology Center, Harper/Grace Hospitals, 48201, Detroit, Michigan, U.S.A aut NATIONALLICENCE 773 0- Clinical & Experimental Metastasis Kluwer Academic Publishers 8/1(1990-01-01), 59-73 0262-0898 8:1<59 1990 8 10585 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer