caa a22 4500 465765114 CHVBK 20180323111911.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF01810676 doi (NATIONALLICENCE)springer-10.1007/BF01810676 Neoplastic invasion in experimental carcinoma of the colon: abnormal differentiation and release of mucus [Elektronische Daten] [I. Carr, K. Orr] Carcinomas of the colon were induced in F344 rats with dimethylhydrazine (20 mg/kg for 12 weeks). The invasive edges of the lesions were examined with the electron microscope. As in human colorectal cancer, the invasive edges show neoplastic cells with abnormal differentiation of apical cytoplasmic rootlets and processes at the basal or invasive edge of the cell, ‘apical reversal'. Mucous carcinoma cells release material into the interstitial connective tissue matrix. The features may contribute to the complex phenomenon of neoplastic invasion. Taylor & Francis Ltd., 1990 Carr I. Departments of Pathology and Immunology, University of Manitoba and St Boniface General Hospital, Winnipeg, Manitoba, Canada aut Orr K. Departments of Pathology and Immunology, University of Manitoba and St Boniface General Hospital, Winnipeg, Manitoba, Canada aut Clinical & Experimental Metastasis Kluwer Academic Publishers 8/4(1990-07-01), 299-304 0262-0898 8:4<299 1990 8 10585 https://doi.org/10.1007/BF01810676 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01810676 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Carr I. Departments of Pathology and Immunology, University of Manitoba and St Boniface General Hospital, Winnipeg, Manitoba, Canada aut NATIONALLICENCE 700 1- Orr K. Departments of Pathology and Immunology, University of Manitoba and St Boniface General Hospital, Winnipeg, Manitoba, Canada aut NATIONALLICENCE 773 0- Clinical & Experimental Metastasis Kluwer Academic Publishers 8/4(1990-07-01), 299-304 0262-0898 8:4<299 1990 8 10585 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer