caa a22 4500 465765165 CHVBK 20180323111911.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF00058154 doi (NATIONALLICENCE)springer-10.1007/BF00058154 The effect of butyric acid and retinoic acid on invasion and experimental metastasis of murine melanoma cells [Elektronische Daten] [T. McGarvey, S. Silberman, B. Persky] : The effect of butyric acid (BA) and all trans-retinoic acid (RA) on murine melanoma cells was investigated in vitro and in vivo. The in vitro assays included 3H-IdUR incorporation, adhesion, migration and invasion experiments. Butyric acid decreased 3H-IdUR cellular incorporation within 24h and increased adhesion as measured by trypsin release of 3H-IdUR labelled cells from either polycarbonate (p.c.) or Matrigel-coated p.c. membranes. Migration and invasion rates after 72h were quantified by scanning electron microscopy (SEM). The invasion barrier consisted of Matrigel-coated p.c. membranes. Butyric acid significantly enhanced migration and invasion of B16a cells, while RA significantly decreased migration and invasion of B1 6a and K-1735 cells. Subcutaneous administration of either BA or RA pellets significantly decreased the number of lung nodules in the experimental metastatic assay. The experimental metastatic assay is defined as a tail vein inoculation protocol followed by subsequent lung evaluation. Taylor & Francis Ltd, 1990 McGarvey T. Departments of Anatomy, Loyola University of Chicago, 2160 South First Avenue, 60153, Maywood, Illinois, U.S.A. aut Silberman S. Department of Pathology, Loyola University of Chicago, 2160 South First Avenue, 60153, Maywood, Illinois, U.S.A. aut Persky B. Departments of Anatomy, Loyola University of Chicago, 2160 South First Avenue, 60153, Maywood, Illinois, U.S.A. aut Clinical & Experimental Metastasis Kluwer Academic Publishers 8/5(1990-09-01), 433-448 0262-0898 8:5<433 1990 8 10585 https://doi.org/10.1007/BF00058154 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00058154 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McGarvey T. Departments of Anatomy, Loyola University of Chicago, 2160 South First Avenue, 60153, Maywood, Illinois, U.S.A aut NATIONALLICENCE 700 1- Silberman S. Department of Pathology, Loyola University of Chicago, 2160 South First Avenue, 60153, Maywood, Illinois, U.S.A aut NATIONALLICENCE 700 1- Persky B. Departments of Anatomy, Loyola University of Chicago, 2160 South First Avenue, 60153, Maywood, Illinois, U.S.A aut NATIONALLICENCE 773 0- Clinical & Experimental Metastasis Kluwer Academic Publishers 8/5(1990-09-01), 433-448 0262-0898 8:5<433 1990 8 10585 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer