caa a22 4500 465765211 CHVBK 20180323111911.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF00058156 doi (NATIONALLICENCE)springer-10.1007/BF00058156 A positive association between agonist-induced cyclic AMP production in vitro and metastatic potential in murine B16 melanoma and hamster fibrosarcoma [Elektronische Daten] [S. Hill, R. Rees, S. MacNeil] : A positive association between agonist-stimulated cyclic AMP production in vitro and both experimentally induced (B16 melanoma) and spontaneous (fibrosarcoma) metastases were found. Five B16 melanoma cell lines producing varying degrees of lung colonization following intravenous injection and three hamster fibrosarcoma cell lines producing a varying number of metastases in lungs and regional lymph nodes after removal of the primary tumour were studied. Agonist-stimulated (forskolin and melanocyte-stimulating hormone), but not basal cyclic AMP accumulation, increased with increasing metastatic potential. This relationship did not extend to other intracellular signalling systems as determined by investigation of basal or foetal-calf stimulated phosphatidylinositol hydrolysis for either tumour type. Intracellular free calcium was also similar in B16 melanoma cell lines of varying metastatic potential. Taylor & Francis Ltd, 1990 Hill S. Department of Medicine, Clinical Sciences Centre, Northern General Hospital, S5 7AU, Sheffield, U.K. aut Rees R. Department of Experimental and Clinical Microbiology, Section of Tumour Biology and Immunology, The Medical School, Beech Hill Road, S10 2RX, Sheffield, U.K. aut MacNeil S. Institute for Cancer Studies, Sheffield University, Sheffield, UK aut Clinical & Experimental Metastasis Kluwer Academic Publishers 8/5(1990-09-01), 461-474 0262-0898 8:5<461 1990 8 10585 https://doi.org/10.1007/BF00058156 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00058156 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hill S. Department of Medicine, Clinical Sciences Centre, Northern General Hospital, S5 7AU, Sheffield, U.K aut NATIONALLICENCE 700 1- Rees R. Department of Experimental and Clinical Microbiology, Section of Tumour Biology and Immunology, The Medical School, Beech Hill Road, S10 2RX, Sheffield, U.K aut NATIONALLICENCE 700 1- MacNeil S. Institute for Cancer Studies, Sheffield University, Sheffield, UK aut NATIONALLICENCE 773 0- Clinical & Experimental Metastasis Kluwer Academic Publishers 8/5(1990-09-01), 461-474 0262-0898 8:5<461 1990 8 10585 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer