caa a22 4500 465765246 CHVBK 20180323111911.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF00117794 doi (NATIONALLICENCE)springer-10.1007/BF00117794 Enhancement of experimental metastatic ability by tumor necrosis factor-alpha alone or in combination with interferon-gamma [Elektronische Daten] [P. Lollini, C. De Giovanni, G. Nicoletti, A. Bontadini, P. Tazzari, L. Landuzzi, K. Scotlandi, P. Nanni] : The effects of recombinant tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on B16 mouse melanoma experimental metastatic ability and major histocompatibility complex (H-2b) antigens expression were studied. B16 cells exposed in vitro to TNF-alpha had an increased H-2 expression and were more metastatic than untreated cells. The simultaneous treatment with TNF-alpha and IFN-gamma amplified the enhancement of experimental metastasis and all other effects obtained with TNF-alpha alone. The B16 clone B78H1, selectively resistant to H-2 induction and to enhancement of metastatic ability by IFN-gamma, was not affected by treatment with TNF-alpha and with TNF-alpha + IFN-gamma. These findings contribute to a better understanding of the pleiotropic effects of TNF, some of which can have opposing actions in the complex tumor-host relationships.[/p] Taylor & Francis Ltd, 1990 Lollini P. Istituto di Cancerologia, Universiti di Bologna, Italy aut De Giovanni C. Istituto di Cancerologia, Universiti di Bologna, Italy aut Nicoletti G. Istituto di Cancerologia, Universiti di Bologna, Italy aut Bontadini A. Istituto di Ematologia ‘L. e A. Seragnoli', Università di Bologna, Italy aut Tazzari P. Istituto di Ematologia ‘L. e A. Seragnoli', Università di Bologna, Italy aut Landuzzi L. Istituto di Cancerologia, Universiti di Bologna, Italy aut Scotlandi K. Istituto di Cancerologia, Universiti di Bologna, Italy aut Nanni P. Istituto di Cancerologia, Universiti di Bologna, Italy aut Clinical & Experimental Metastasis Kluwer Academic Publishers 8/2(1990-03-01), 215-224 0262-0898 8:2<215 1990 8 10585 https://doi.org/10.1007/BF00117794 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00117794 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lollini P. Istituto di Cancerologia, Universiti di Bologna, Italy aut NATIONALLICENCE 700 1- De Giovanni C. Istituto di Cancerologia, Universiti di Bologna, Italy aut NATIONALLICENCE 700 1- Nicoletti G. Istituto di Cancerologia, Universiti di Bologna, Italy aut NATIONALLICENCE 700 1- Bontadini A. Istituto di Ematologia ‘L. e A. Seragnoli', Università di Bologna, Italy aut NATIONALLICENCE 700 1- Tazzari P. Istituto di Ematologia ‘L. e A. Seragnoli', Università di Bologna, Italy aut NATIONALLICENCE 700 1- Landuzzi L. Istituto di Cancerologia, Universiti di Bologna, Italy aut NATIONALLICENCE 700 1- Scotlandi K. Istituto di Cancerologia, Universiti di Bologna, Italy aut NATIONALLICENCE 700 1- Nanni P. Istituto di Cancerologia, Universiti di Bologna, Italy aut NATIONALLICENCE 773 0- Clinical & Experimental Metastasis Kluwer Academic Publishers 8/2(1990-03-01), 215-224 0262-0898 8:2<215 1990 8 10585 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer