caa a22 4500 465765270 CHVBK 20180323111912.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF00117787 doi (NATIONALLICENCE)springer-10.1007/BF00117787 The identification of a neutral glycosphingolipid antigenic marker for metastatic cells in the R3230AC rat mammary adenocarcinoma [Elektronische Daten] [Svein Carlsen, Michele Barry, Karen Newton] : The process of metastasis is a complex process involving numerous steps, and it is thought that cells able to complete all of these steps and form metastatic foci form a unique subpopulation of cells within the tumor. To study this metastatic subpopulation, a marker for the metastatic cells is required. We have previously described the enrichment of soybean agglutinin binding cells in tumor populations enriched for lymphatic metastasis [1]. In this study we provide evidence that the cell-surface structure binding soybean agglutinin is a neutral glycosphingolipid. Using monoclonal antibodies generated against this glycolipid, highly metastatic tumor populations were depleted of cells containing this glycolipid. These depleted cell populations were found to be equally tumorigenic to that of the untreated population but were much less metastatic. These results suggest that this glycolipid may be a useful marker for metastatic cells. Taylor & Francis Ltd, 1990 Carlsen Svein Department of Microbiology, College of Medicine, University of Saskatchewan, S7N 0W0, Saskatoon, Saskatchewan, Canada aut Barry Michele Department of Microbiology, College of Medicine, University of Saskatchewan, S7N 0W0, Saskatoon, Saskatchewan, Canada aut Newton Karen Department of Microbiology, College of Medicine, University of Saskatchewan, S7N 0W0, Saskatoon, Saskatchewan, Canada aut Clinical & Experimental Metastasis Kluwer Academic Publishers 8/2(1990-03-01), 141-151 0262-0898 8:2<141 1990 8 10585 https://doi.org/10.1007/BF00117787 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00117787 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Carlsen Svein Department of Microbiology, College of Medicine, University of Saskatchewan, S7N 0W0, Saskatoon, Saskatchewan, Canada aut NATIONALLICENCE 700 1- Barry Michele Department of Microbiology, College of Medicine, University of Saskatchewan, S7N 0W0, Saskatoon, Saskatchewan, Canada aut NATIONALLICENCE 700 1- Newton Karen Department of Microbiology, College of Medicine, University of Saskatchewan, S7N 0W0, Saskatoon, Saskatchewan, Canada aut NATIONALLICENCE 773 0- Clinical & Experimental Metastasis Kluwer Academic Publishers 8/2(1990-03-01), 141-151 0262-0898 8:2<141 1990 8 10585 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer