caa a22 4500 465765297 CHVBK 20180323111912.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF00117789 doi (NATIONALLICENCE)springer-10.1007/BF00117789 Reduction of metastasis in a murine mammary tumour model by heparin and polyinosinic-polycytidylic acid [Elektronische Daten] [A. Lee, L. Rogers, J. Longcroft, R. Jeffery] : A murine mammary tumour model has been used to test the efficacy of a combination of heparin and the interferon inducer, poly I : C on spontaneous metastasis from a s.c. primary tumour and on experimental metastasis following i.v. injection of tumour cells. This treatment has no effect on the growth of primary tumours, but lung metastases arising from these tumours were reduced. When tumour cells were injected i.v. the number of lung colonies was significantly reduced and survival time extended. Short-term treatment did not prevent the subsequent growth of extravasated, but dormant tumour cells, although mice treated for 8 or 12 weeks survived at least 6 months without any sign of lung colonies. Several mechanisms may contribute to the overall effect of this treatment; a reduction in the mitotic indices of lung colonies (observed in poly I : C treated mice) and also NK cells appeared to be important for the effectiveness of poly I : C since the reduction in experimental metastasis was abrogated by concomitant treatment with anti-asialo GM1 serum. Taylor & Francis Ltd, 1990 Lee A. Hormone Physiology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, PO Box 123, WC2A 3PX, London, U.K. aut Rogers L. Hormone Physiology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, PO Box 123, WC2A 3PX, London, U.K. aut Longcroft J. Hormone Physiology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, PO Box 123, WC2A 3PX, London, U.K. aut Jeffery R. Hormone Physiology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, PO Box 123, WC2A 3PX, London, U.K. aut Clinical & Experimental Metastasis Kluwer Academic Publishers 8/2(1990-03-01), 165-171 0262-0898 8:2<165 1990 8 10585 https://doi.org/10.1007/BF00117789 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00117789 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee A. Hormone Physiology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, PO Box 123, WC2A 3PX, London, U.K aut NATIONALLICENCE 700 1- Rogers L. Hormone Physiology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, PO Box 123, WC2A 3PX, London, U.K aut NATIONALLICENCE 700 1- Longcroft J. Hormone Physiology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, PO Box 123, WC2A 3PX, London, U.K aut NATIONALLICENCE 700 1- Jeffery R. Hormone Physiology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, PO Box 123, WC2A 3PX, London, U.K aut NATIONALLICENCE 773 0- Clinical & Experimental Metastasis Kluwer Academic Publishers 8/2(1990-03-01), 165-171 0262-0898 8:2<165 1990 8 10585 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer