caa a22 4500 465765300 CHVBK 20180323111912.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF00117793 doi (NATIONALLICENCE)springer-10.1007/BF00117793 Inhibition of lung colonization of mouse colon 26 adenocarcinoma by recombinant mouse interferon β through a modification of platelet function [Elektronische Daten] [T. Tsuruo, H. Saito, M. Watanabe, Y. Sugimoto, T. Yamori, T. Oh-Hara] : Recombinant murine interferon β (MuIFN-β) given i.v. efficiently inhibited both pulmonary arrest and formation of lung colonies of NL-17, a highly metastatic variant of mouse colon adenocarcinoma 26. NL-17 was rather resistant to MuIFN-β in vitro and was highly resistant to natural killer cells of mice even though they were treated in vivo with MuIFN-β. Platelets isolated from MuIFN-β-treated mice showed reduced aggregating activity induced by NL-17. Since lung colonization by NL-17 is influenced by platelet aggregation, the inhibition of colonization by MuIFN-β could be partly mediated through modification of platelet function in vivo. The effect of MuIFN-β on platelet function and its subsequent inhibition of lung colony formation give new insights into the action of recombinant MuIFN-β. Taylor & Francis Ltd, 1990 Tsuruo T. Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 170, Kami-Ikebukuro, Toshima-ku, Tokyo aut Saito H. Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 170, Kami-Ikebukuro, Toshima-ku, Tokyo aut Watanabe M. Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 170, Kami-Ikebukuro, Toshima-ku, Tokyo aut Sugimoto Y. Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 170, Kami-Ikebukuro, Toshima-ku, Tokyo aut Yamori T. Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 170, Kami-Ikebukuro, Toshima-ku, Tokyo aut Oh-Hara T. Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 170, Kami-Ikebukuro, Toshima-ku, Tokyo aut Clinical & Experimental Metastasis Kluwer Academic Publishers 8/2(1990-03-01), 203-213 0262-0898 8:2<203 1990 8 10585 https://doi.org/10.1007/BF00117793 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00117793 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tsuruo T. Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 170, Kami-Ikebukuro, Toshima-ku, Tokyo aut NATIONALLICENCE 700 1- Saito H. Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 170, Kami-Ikebukuro, Toshima-ku, Tokyo aut NATIONALLICENCE 700 1- Watanabe M. Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 170, Kami-Ikebukuro, Toshima-ku, Tokyo aut NATIONALLICENCE 700 1- Sugimoto Y. Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 170, Kami-Ikebukuro, Toshima-ku, Tokyo aut NATIONALLICENCE 700 1- Yamori T. Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 170, Kami-Ikebukuro, Toshima-ku, Tokyo aut NATIONALLICENCE 700 1- Oh-Hara T. Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 170, Kami-Ikebukuro, Toshima-ku, Tokyo aut NATIONALLICENCE 773 0- Clinical & Experimental Metastasis Kluwer Academic Publishers 8/2(1990-03-01), 203-213 0262-0898 8:2<203 1990 8 10585 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer