caa a22 4500 465765319 CHVBK 20180323111912.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF00117788 doi (NATIONALLICENCE)springer-10.1007/BF00117788 N -methylformamide affects spontaneous metastases of 3LL lines and increases natural killer activity of tumor-bearing mice [Elektronische Daten] [C. Greco, D. Del Bufalo, D. Giannarelli, M. Marangolo, M. Fuggetta, E. Bonmassar, G. Zupi] : The antitumor activity of the polar solvent N-methylformamide (NMF) was evaluated on three lines derived from the Lewis lung carcinoma (3 LL), endowed with different metastatic potential. Two administration schedules were tested, these being repeated regimens of NM F (200 mg/kg per dose) for 12 consecutive days, starting 24 h or 6-10 days after tumor implantation (early or late treatment, respectively). The results of the present work can be summarized as follows: (1) NMF regimens did not greatly affect tumor growth behavior of 3LL lines; conversely, they markedly influenced their spontaneous colonizing ability in the lungs, either by delaying early metastatic spread or by reducing the number and size of pulmonary metastases already implanted. (2) A significant increase of NK cell activity during and after early treatment with NMF was observed in the more-metastasizing lines, thus suggesting the possibility of an immunomodulating effect of NMF. Taylor & Francis Ltd, 1990 Greco C. Experimental Chemotherapy Laboratory, Regina Elena Institute for Cancer Research, Rome, Italy aut Del Bufalo D. Experimental Chemotherapy Laboratory, Regina Elena Institute for Cancer Research, Rome, Italy aut Giannarelli D. Medical Physics and Expert Systems Laboratory, Regina Elena Institute for Cancer Research, Rome, Italy aut Marangolo M. Medical Oncology Unit, City Hospital of Ravenna, Italy aut Fuggetta M. Experimental Medicine Institute, National Council of Research, Rome, Italy aut Bonmassar E. Experimental Medicine and Biochemical Science Department, School of Medicine, II University of Rome, Italy aut Zupi G. Experimental Chemotherapy Laboratory, Regina Elena Institute for Cancer Research, Rome, Italy aut Clinical & Experimental Metastasis Kluwer Academic Publishers 8/2(1990-03-01), 153-163 0262-0898 8:2<153 1990 8 10585 https://doi.org/10.1007/BF00117788 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00117788 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Greco C. Experimental Chemotherapy Laboratory, Regina Elena Institute for Cancer Research, Rome, Italy aut NATIONALLICENCE 700 1- Del Bufalo D. Experimental Chemotherapy Laboratory, Regina Elena Institute for Cancer Research, Rome, Italy aut NATIONALLICENCE 700 1- Giannarelli D. Medical Physics and Expert Systems Laboratory, Regina Elena Institute for Cancer Research, Rome, Italy aut NATIONALLICENCE 700 1- Marangolo M. Medical Oncology Unit, City Hospital of Ravenna, Italy aut NATIONALLICENCE 700 1- Fuggetta M. Experimental Medicine Institute, National Council of Research, Rome, Italy aut NATIONALLICENCE 700 1- Bonmassar E. Experimental Medicine and Biochemical Science Department, School of Medicine, II University of Rome, Italy aut NATIONALLICENCE 700 1- Zupi G. Experimental Chemotherapy Laboratory, Regina Elena Institute for Cancer Research, Rome, Italy aut NATIONALLICENCE 773 0- Clinical & Experimental Metastasis Kluwer Academic Publishers 8/2(1990-03-01), 153-163 0262-0898 8:2<153 1990 8 10585 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer