caa a22 4500 465766080 CHVBK 20180323111914.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02544328 doi (NATIONALLICENCE)springer-10.1007/BF02544328 The effect of alfalfa-corn diets on cholesterol metabolism and gallstones in prairie dogs [Elektronische Daten] [Bertram Cohen, Erwin Mosbach, Naoguki Matoba, Sung Suh, Charles McSherry] Cholesterol gallstones were present in prairie dogs fed alfalfa plus corn with and without exogenous cholesterol (0.4%). The diets fed to the animals for eight weeks contained alfalfa plus corn in fixed proportions of 50∶50, 85∶15 and 15∶85 (w/w). At sacrifice, all animals were healthy but had not gained weight; no deaths occurred during the experiment. Cholesterol gallstones were present in all groups. In the absence of exogenous cholesterol, the highest stone incidence was found in the animals which received the lowest fiber (highest corn) diets (alfalfa plus corn, 50∶50, 67%; alfalfa plus corn, 15∶85, 83%). Cholesterol gallstone incidence was 100% when exogenous cholesterol was added to the alfalfa plus corn diets (50∶50 and 15∶85). No pigment gallstones were detected in any animal. Liver and plasma cholesterol concentrations were highest in the animals receiving alfalfa plus corn (15∶85) plus 0.4% cholesterol (4.29 mg/g, and 356 mg/dl, respectively). These values were lowest in animals receiving 85% alfalfa plus 15% corn without cholesterol (2.19 mg/g and 88 mg/dl, respectively). Lithogenic indices were below 1.00 in all groups. Biliary bile acids were mainly amidates of cholic acid and chenodeoxycholic acid, with the former predominating. Thus, gallstones can be formed in prairie dogs in the absence of exogenous cholesterol; gallstone incidence is reduced by dietary fiber. American Oil Chemists' Society (AOCS), 1985 Cohen Bertram Department of Surgery, Beth Israel Medical Center, First Ave. at 16th St., 10003, New York, NY aut Mosbach Erwin Department of Surgery, Beth Israel Medical Center, First Ave. at 16th St., 10003, New York, NY aut Matoba Naoguki Department of Surgery, Beth Israel Medical Center, First Ave. at 16th St., 10003, New York, NY aut Suh Sung Department of Surgery, Beth Israel Medical Center, First Ave. at 16th St., 10003, New York, NY aut McSherry Charles Department of Surgery, Beth Israel Medical Center, First Ave. at 16th St., 10003, New York, NY aut Lipids Springer-Verlag 25/3(1990-03-01), 143-148 0024-4201 25:3<143 1990 25 11745 https://doi.org/10.1007/BF02544328 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02544328 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cohen Bertram Department of Surgery, Beth Israel Medical Center, First Ave. at 16th St., 10003, New York, NY aut NATIONALLICENCE 700 1- Mosbach Erwin Department of Surgery, Beth Israel Medical Center, First Ave. at 16th St., 10003, New York, NY aut NATIONALLICENCE 700 1- Matoba Naoguki Department of Surgery, Beth Israel Medical Center, First Ave. at 16th St., 10003, New York, NY aut NATIONALLICENCE 700 1- Suh Sung Department of Surgery, Beth Israel Medical Center, First Ave. at 16th St., 10003, New York, NY aut NATIONALLICENCE 700 1- McSherry Charles Department of Surgery, Beth Israel Medical Center, First Ave. at 16th St., 10003, New York, NY aut NATIONALLICENCE 773 0- Lipids Springer-Verlag 25/3(1990-03-01), 143-148 0024-4201 25:3<143 1990 25 11745 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer