caa a22 4500 465766226 CHVBK 20180323111914.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02536015 doi (NATIONALLICENCE)springer-10.1007/BF02536015 Erythrocyte membrane lipid alterations in undernourished cerebral palsied children during high intakes of a soy oil-based enteral formula [Elektronische Daten] [Mary Harper, John Patrick, John Kramer, Mark Wolynetz] Five undernourished children with severe cerebral palsy (CP) were tube-fed sufficient volumes of IsocalTM to allow rapid weight gain. IsocalTM provided, on average, 88% of their daily energy intake for at least 25 days. The purpose of our study was to correct the undernutrition and to analyze the major erythrocyte phospholipids before and after feeding periods for possible feeding and disease-related differences. The fatty acid profiles of erythrocyte membranes from CP children were compared with those from 12 healthy children and with the fatty acid composition of the formula. There were no clinical or biochemical indications of essential fatty acid deficiency. The feeding of a soy oil-based formula increased the proportions of 18∶2n−6 in the phospholipids. The increases occurred predominantly in phosphatidylcholine followed by phosphatidylethanolamine. Despite such large dietary intakes of soy oil, no changes were observed in the phospholipid concentrations of 20∶4n−6, 18∶3n−3, 20∶5n−3, or in the C22n−6 and C22n−3 fatty acids. These findings are consistent with an inhibition of the Δ6 desaturase by high dietary linoleate. American Oil Chemists' Society, 1990 Harper Mary Department of Biochemistry, University of Ottawa, 451 Smyth Rd., K1H 8M5, Ottawa, Ontario, Canada aut Patrick John Department of Biochemistry, University of Ottawa, 451 Smyth Rd., K1H 8M5, Ottawa, Ontario, Canada aut Kramer John Animal Research Center, Agriculture Canada, Ottawa, Ontario, Canada aut Wolynetz Mark Research Program Service, Agriculture Canada, Ottawa, Ontario, Canada aut Lipids Springer-Verlag 25/10(1990-10-01), 639-645 0024-4201 25:10<639 1990 25 11745 https://doi.org/10.1007/BF02536015 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02536015 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Harper Mary Department of Biochemistry, University of Ottawa, 451 Smyth Rd., K1H 8M5, Ottawa, Ontario, Canada aut NATIONALLICENCE 700 1- Patrick John Department of Biochemistry, University of Ottawa, 451 Smyth Rd., K1H 8M5, Ottawa, Ontario, Canada aut NATIONALLICENCE 700 1- Kramer John Animal Research Center, Agriculture Canada, Ottawa, Ontario, Canada aut NATIONALLICENCE 700 1- Wolynetz Mark Research Program Service, Agriculture Canada, Ottawa, Ontario, Canada aut NATIONALLICENCE 773 0- Lipids Springer-Verlag 25/10(1990-10-01), 639-645 0024-4201 25:10<639 1990 25 11745 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer