caa a22 4500 465766471 CHVBK 20180323111915.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF02538091 doi (NATIONALLICENCE)springer-10.1007/BF02538091 Phospholipid fatty acid composition of various mouse tissues after feeding α-linolenate (18∶3n−3) or eicosatrienoate (20∶3n−3) [Elektronische Daten] [Alvin Berger, J. German] The selective incorporation of dietary α-linolenate (18∶3n−3) and its elongation product, eicosatrienoate (20∶3n−3), into various phospholipids (PL) of mouse liver, spleen, kidney, and heart, was examined in a two-week feeding trial by assessing mol % changes in associated fatty acids. Mice were fed fat-free AIN 76A diets modified with either 2 wt% safflower oil (control); 1% safflower and 1% linolenate; or 1% safflower and 1% eicosatrienoate. After linolenate or eicosatrienoate feeding, 20∶4n−6 was reduced by 36-50% in liver phosphatidylcholine (PC) and in liver and spleen phosphatidylethanolamine (PE). Linolenate was minimally incorporated into PL, but was desaturated and elongated to 20∶5n−3, 22∶5n−3, and 22∶6n−3, with notable differences in the quantity of these n−3 derivatives associated with different tissues and PL. Eicosatrientoate was uniquely incorporated into the cardiolipin (CL) pool of all organs. There was also considerable retroconversion of 20∶3n−3 to 18∶3n−3 (PC, PE). Dietary eicosatrienoate may therefore affect metabolism in diverse ways—20∶3n−3, which is retroconverted to 18∶3n−3, may provide substrate for 20∶5n−3 and 22∶6n−3 syntheses, whereas intact 20∶3n−3 may be incorporated into the CL pool. Acyl modifications of CL are known to affect the activity of key innermitochondrial enzymes, such as cytochrome c oxidase. American Oil Chemists' Society (AOCS), 1990 Berger Alvin Department of Food Science, University of California at Davis, 1480 Chemistry Annex, 95616, Davis, California aut German J. Department of Food Science, University of California at Davis, 1480 Chemistry Annex, 95616, Davis, California aut Lipids Springer-Verlag 25/8(1990-08-01), 473-480 0024-4201 25:8<473 1990 25 11745 https://doi.org/10.1007/BF02538091 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02538091 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Berger Alvin Department of Food Science, University of California at Davis, 1480 Chemistry Annex, 95616, Davis, California aut NATIONALLICENCE 700 1- German J. Department of Food Science, University of California at Davis, 1480 Chemistry Annex, 95616, Davis, California aut NATIONALLICENCE 773 0- Lipids Springer-Verlag 25/8(1990-08-01), 473-480 0024-4201 25:8<473 1990 25 11745 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer