caa a22 4500 46576648X CHVBK 20180323111915.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF02538083 doi (NATIONALLICENCE)springer-10.1007/BF02538083 Lipids in gap junction assembly and function [Elektronische Daten] [Barbara Malewicz, V. Kumar, Ross Johnson, Wolfgang Baumann] Gap junctions (GJ) are important regulators of cellular function. They provide channels for the direct movement of small molecules between cells and thus control cell-to-cell transfer of metabolites and the transmission of various stimuli. Gap junctions have been shown to be involved in a multitude of cellular processes ranging from cell synchronization and neuronal function to cell differentiation and carcinogenesis. Much knowledge has been gained in recent years concerning the structure and molecular organization of GJ proteins; yet, the mechanisms that control and modulate gap junction assembly and function are still not well understood. Although it is quite apparent that the GJ proteins assemble in the lipid milieu of the plasma membrane, and that the cluster of proteins assembled in the junction do function in a lipid environment, there is a general paucity of information on the role of lipids in the gap junction assembly process and in the function of gap junctions. The present review is a comprehensive account of current knowledge on gap junction lipids. We also discuss what is known to date on the involvement of lipids in gap junction formation. Special emphasis is being placed on the potential role of membrane cholesterol in gap junction assembly and function. American Oil Chemists' Society (AOCS), 1990 Malewicz Barbara The Hormel Institute, University of Minnesota, 55912, Austin, Minnesota aut Kumar V. The Hormel Institute, University of Minnesota, 55912, Austin, Minnesota aut Johnson Ross Department of Genetics and Cell Biology, University of Minnesota, 55108, St. Paul, Minnesota aut Baumann Wolfgang The Hormel Institute, University of Minnesota, 55912, Austin, Minnesota aut Lipids Springer-Verlag 25/8(1990-08-01), 419-427 0024-4201 25:8<419 1990 25 11745 https://doi.org/10.1007/BF02538083 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02538083 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Malewicz Barbara The Hormel Institute, University of Minnesota, 55912, Austin, Minnesota aut NATIONALLICENCE 700 1- Kumar V. The Hormel Institute, University of Minnesota, 55912, Austin, Minnesota aut NATIONALLICENCE 700 1- Johnson Ross Department of Genetics and Cell Biology, University of Minnesota, 55108, St. Paul, Minnesota aut NATIONALLICENCE 700 1- Baumann Wolfgang The Hormel Institute, University of Minnesota, 55912, Austin, Minnesota aut NATIONALLICENCE 773 0- Lipids Springer-Verlag 25/8(1990-08-01), 419-427 0024-4201 25:8<419 1990 25 11745 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer