caa a22 4500 465766625 CHVBK 20180323111915.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF02562216 doi (NATIONALLICENCE)springer-10.1007/BF02562216 Synergism between penicillin G and the antimicrobial ether lipid, rac -1-dodecylglycerol, acting below its critical micelle concentration [Elektronische Daten] [H. Ved, Evan Gustow, Ronald Pieringer] rac-1-Dodecylglycerol (DDG) and penicillin G (Pen G) act synergistically to dramatically lower the minimum inhibitory concentration (MIC) of each other in four Gram-positive bacteria studied. At one-half its MIC, DDG ether lowered the MIC of Pen G 10- to 80-fold. Under the same conditions, Pen G lowered the MIC of DDG 4- to 7.5-fold. The critical micelle concentration of DDG was determined to be 7.93 mg/ml (0.0305 mM), which is approximately two-fold greater than the minimum inhibitory concentration of DDG determined in the presence of a protein-free chemically defined medium. This finding suggests that DDG is not killing bacteria through its detergent action. Pen G also did not alter the critical micelle concentration of DDG, which indicates that the synergism between these two agents is not related to micelle formation. American Oil Chemists' Society, 1990 Ved H. Department of Biochemistry, Temple University School of Medicine, 19140, Philadelphia, PA aut Gustow Evan Department of Biochemistry, Temple University School of Medicine, 19140, Philadelphia, PA aut Pieringer Ronald Department of Biochemistry, Temple University School of Medicine, 19140, Philadelphia, PA aut Lipids Springer-Verlag 25/2(1990-02-01), 119-121 0024-4201 25:2<119 1990 25 11745 https://doi.org/10.1007/BF02562216 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02562216 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ved H. Department of Biochemistry, Temple University School of Medicine, 19140, Philadelphia, PA aut NATIONALLICENCE 700 1- Gustow Evan Department of Biochemistry, Temple University School of Medicine, 19140, Philadelphia, PA aut NATIONALLICENCE 700 1- Pieringer Ronald Department of Biochemistry, Temple University School of Medicine, 19140, Philadelphia, PA aut NATIONALLICENCE 773 0- Lipids Springer-Verlag 25/2(1990-02-01), 119-121 0024-4201 25:2<119 1990 25 11745 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer