caa a22 4500 465766706 CHVBK 20180323111916.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF02562209 doi (NATIONALLICENCE)springer-10.1007/BF02562209 Isolation of a guanine-malondialdehyde adduct from rat and human urine [Elektronische Daten] [M. Hadley, H. Draper] A 1∶1 adduct of guanine with malondialdehyde (MDA) was isolated from rat and human urine. This compound was shown to be identical to a synthetic adduct prepared according to the procedure of Setoet al. (Bull. Chem. Soc. Jpn. 58, 3431-3435, 1985). The UV, NMR and other characteristics of the compound were consistent with the tricyclic pyrimidinopurine structure proposed by these investigators. Its endogenous origin is indicated by its presence in the urine of rats fed an MDA-free diet, and by the observation that its excretion increased following iron or carbon tetrachloride administration. It may serve as a marker for nucleic acid modification caused by lipid peroxidationin vivo. American Oil Chemists' Society, 1990 Hadley M. Department of Nutritional Sciences, College of Biological Science, University of Guelph, N1G 2W1, Guelph, Ontario, Canada aut Draper H. Department of Nutritional Sciences, College of Biological Science, University of Guelph, N1G 2W1, Guelph, Ontario, Canada aut Lipids Springer-Verlag 25/2(1990-02-01), 82-85 0024-4201 25:2<82 1990 25 11745 https://doi.org/10.1007/BF02562209 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02562209 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hadley M. Department of Nutritional Sciences, College of Biological Science, University of Guelph, N1G 2W1, Guelph, Ontario, Canada aut NATIONALLICENCE 700 1- Draper H. Department of Nutritional Sciences, College of Biological Science, University of Guelph, N1G 2W1, Guelph, Ontario, Canada aut NATIONALLICENCE 773 0- Lipids Springer-Verlag 25/2(1990-02-01), 82-85 0024-4201 25:2<82 1990 25 11745 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer