caa a22 4500 465766773 CHVBK 20180323111916.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF02544037 doi (NATIONALLICENCE)springer-10.1007/BF02544037 Effects of triton WR 1339 and heparin on the transfer of surface lipids from triglyceride-rich emulsions to high density lipoproteins in rats [Elektronische Daten] [Raul Maranhão, Ivete Roland, Mário Hirata] The influence of lipolytic mechanisms on the transfer of phospholipids and unesterified cholesterol from artificial emulsions, serving as chylomicron models to other plasma lipoproteins, mainly high density lipoproteins (HDL) were testedin vivo. The emulsions labeled with radioactive lipids were injected into the bloodstream of rats (controls) and the results were compared with those obtained from rats that had previously been treated with Triton WR 1339 or heparin. Plasma clearance and the distribution of cholesteryl esters, phospholipids and unesterified cholesterol in the different plasma lipoprotein fractions were then determined. Whereas virtually no cholesteryl esters were found in d>1.006 g/mL density fraction of the three experimental groups, 2.8±1.3% of the injected phospholipids were in the 1.063-1.210 g/L density fraction of the Triton treated rats, and 12.6±5.4% of the heparin treated rats, as compared to 10.1±1.7% in controls. This indicates that lipolysis directly influences phospholipid transfer to HDL. In contrast, free-cholesterol transfer to HDL, besides being less pronounced than phospholipid transfer, was enhanced by Triton and diminished by heparin, indicating that lipolytic mechanisms were not important determinants in this process. American Oil Chemists' Society, 1985 Maranhão Raul The Heart Institute of the São Paulo University Medical School Hospital (Instituto do Caração HC-FMUSP) and Faculty of Pharmaceutical Sciences of the São Paulo University, São Paulo, Brazil aut Roland Ivete The Heart Institute of the São Paulo University Medical School Hospital (Instituto do Caração HC-FMUSP) and Faculty of Pharmaceutical Sciences of the São Paulo University, São Paulo, Brazil aut Hirata Mário The Heart Institute of the São Paulo University Medical School Hospital (Instituto do Caração HC-FMUSP) and Faculty of Pharmaceutical Sciences of the São Paulo University, São Paulo, Brazil aut Lipids Springer-Verlag 25/11(1990-11-01), 701-705 0024-4201 25:11<701 1990 25 11745 https://doi.org/10.1007/BF02544037 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02544037 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maranhão Raul The Heart Institute of the São Paulo University Medical School Hospital (Instituto do Caração HC-FMUSP) and Faculty of Pharmaceutical Sciences of the São Paulo University, São Paulo, Brazil aut NATIONALLICENCE 700 1- Roland Ivete The Heart Institute of the São Paulo University Medical School Hospital (Instituto do Caração HC-FMUSP) and Faculty of Pharmaceutical Sciences of the São Paulo University, São Paulo, Brazil aut NATIONALLICENCE 700 1- Hirata Mário The Heart Institute of the São Paulo University Medical School Hospital (Instituto do Caração HC-FMUSP) and Faculty of Pharmaceutical Sciences of the São Paulo University, São Paulo, Brazil aut NATIONALLICENCE 773 0- Lipids Springer-Verlag 25/11(1990-11-01), 701-705 0024-4201 25:11<701 1990 25 11745 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer