caa a22 4500 46576679X CHVBK 20180323111916.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF02544040 doi (NATIONALLICENCE)springer-10.1007/BF02544040 Effects of dietary fats on prostanoid production and aortic and plasma fatty acid composition in rats [Elektronische Daten] [M. Steel, J. Naughton, G. Hopkins, A. Sinclair, K. O'Dea] Male Sprague-Dawley rats were fed diets with 10%, 30%, or 50% of energy derived from fat for two weeks. The fats used were beef tallow, olive oil, peanut oil and butter. Aortic prostacyclin (PGI2) production, platelet aggregation and thromboxane A2 (TXA2) production and plasma and aortic phospholipid (PL) content were measured. Butter- and beef tallow-feeding reduced aortic PGI2 production and collagen-induced TXA2 production in a dosedependent manner as the level of fat in the diet increased. Neither olive oil nor peanut oil had any effect on aortic PGI2 production or collagen-induced TXA2 production. Butter-feeding also resulted in a decrease in collageninduced platelet aggregation; however, none of the other fats had any effect on collagen-induced platelet aggregation. The observed decreases in aortic PGI2 and collagen-induced TXA2 production were paralleled by similar decreases in aortic and plasma PL arachidonic acid content and an increase in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Only the most saturated fats, butter and beef tallow, had significant inhibitory effects on prostanoid production and platelet aggregation. American Oil Chemists' Society, 1985 Steel M. Department of Medicine, Royal Melboume Hospital, University of Melbourne, 3050, Parkville, Victoria aut Naughton J. Department of Medicine, Royal Melboume Hospital, University of Melbourne, 3050, Parkville, Victoria aut Hopkins G. Department of Applied Biology, RMIT, 3001, Victoria aut Sinclair A. Department of Applied Biology, RMIT, 3001, Victoria aut O'Dea K. Department of Human Nutrition, Deakin University, 3217, Geelong, Victoria, Australia aut Lipids Springer-Verlag 25/11(1990-11-01), 719-723 0024-4201 25:11<719 1990 25 11745 https://doi.org/10.1007/BF02544040 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02544040 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Steel M. Department of Medicine, Royal Melboume Hospital, University of Melbourne, 3050, Parkville, Victoria aut NATIONALLICENCE 700 1- Naughton J. Department of Medicine, Royal Melboume Hospital, University of Melbourne, 3050, Parkville, Victoria aut NATIONALLICENCE 700 1- Hopkins G. Department of Applied Biology, RMIT, 3001, Victoria aut NATIONALLICENCE 700 1- Sinclair A. Department of Applied Biology, RMIT, 3001, Victoria aut NATIONALLICENCE 700 1- O'Dea K. Department of Human Nutrition, Deakin University, 3217, Geelong, Victoria, Australia aut NATIONALLICENCE 773 0- Lipids Springer-Verlag 25/11(1990-11-01), 719-723 0024-4201 25:11<719 1990 25 11745 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer