caa a22 4500 465766846 CHVBK 20180323111916.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF02544042 doi (NATIONALLICENCE)springer-10.1007/BF02544042 Myocardial changes in newborn piglets fed sow milk or milk replacer diets containing different levels of erucic acid [Elektronische Daten] [John Kramer, Edward Farnworth, Kathleen Johnston, Mark Wolynetz, H. Modler, Frank Sauer] This study was undertaken to determine whether the neonate was more susceptible to the effects of dietary erucic acid (22∶1n−9) than the adult. Newborn piglets were used to assess the safety of different levels of 22∶1n−9 on lipid and histological changes in the heart. Newborn piglets showed no myocardial lipidosis as assessed by oil red 0 staining, but lipidosis appeared with consumption of sow milk and disappeared by seven days of age. Milk replacer diets containing soybean oil, or rapeseed oil mixtures with up to 5% 22∶1n−9 in the oil, or 1.25% in the diet, gave trace myocardial lipidosis. Rapeseed oil mixtures with 7 to 42.9% 22∶1n−9 showed definite myocardial lipidosis in newborn piglets, which correlated to dietary 22∶1n−9, showing a maximum after one week on diet. The severity of the lipidosis was greater than observed previously with weaned pigs. There were no significant differences among diets in cardiac lipid classes except for triacylglycerol (TAG), which increased in piglets fed a repeseed oil with 42.9% 22∶1n−9. TAG showed the highest incorporation of 22∶1n−9, the concentration of 22∶1n−9 in TAG was similar to that present in the dietary oil. Among the cardiac phospholipids, sphingomyelin and phosphatidylserine had the highest, and diphosphatidylglycerol (DPG) the lowest level of 22∶1n−9. The low content of 22∶1n−9 in DPG of newborn piglets is not observed in weaned pigs and rats fed high erucic acid rapeseed oil. The relative concentration of saturated fatty acids was lowered in all cardiac phospholipids of piglets fed rapeseed oils, possibly due to the low content of saturated fatty acids in rapeseed oils. The results suggest that piglets fed up to 750 mg 22∶1n−9/kg body weight/day showed no adverse nutritional or cardiac effects. American Oil Chemists' Society, 1985 Kramer John Animal Research Center, Research Branch, Agriculture Canada, K1A OC6, Ottawa, Ontario aut Farnworth Edward Animal Research Center, Research Branch, Agriculture Canada, K1A OC6, Ottawa, Ontario aut Johnston Kathleen Animal Diseases Research Institute, K2H 8P9, Nepean, Ontario, Canada aut Wolynetz Mark Engineering and Statistical Research Center, Research Branch, Agriculture Canada, K1A OC6, Ottawa, Ontario aut Modler H. Food Research Center, Research Branch, Agriculture Canada, K1A OC6, Ottawa, Ontario aut Sauer Frank Animal Research Center, Research Branch, Agriculture Canada, K1A OC6, Ottawa, Ontario aut Lipids Springer-Verlag 25/11(1990-11-01), 729-737 0024-4201 25:11<729 1990 25 11745 https://doi.org/10.1007/BF02544042 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02544042 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kramer John Animal Research Center, Research Branch, Agriculture Canada, K1A OC6, Ottawa, Ontario aut NATIONALLICENCE 700 1- Farnworth Edward Animal Research Center, Research Branch, Agriculture Canada, K1A OC6, Ottawa, Ontario aut NATIONALLICENCE 700 1- Johnston Kathleen Animal Diseases Research Institute, K2H 8P9, Nepean, Ontario, Canada aut NATIONALLICENCE 700 1- Wolynetz Mark Engineering and Statistical Research Center, Research Branch, Agriculture Canada, K1A OC6, Ottawa, Ontario aut NATIONALLICENCE 700 1- Modler H. Food Research Center, Research Branch, Agriculture Canada, K1A OC6, Ottawa, Ontario aut NATIONALLICENCE 700 1- Sauer Frank Animal Research Center, Research Branch, Agriculture Canada, K1A OC6, Ottawa, Ontario aut NATIONALLICENCE 773 0- Lipids Springer-Verlag 25/11(1990-11-01), 729-737 0024-4201 25:11<729 1990 25 11745 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer