caa a22 4500 465766889 CHVBK 20180323111916.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF02544038 doi (NATIONALLICENCE)springer-10.1007/BF02544038 Effects of bile acid feeding on hepatic deoxycholate 7α-hydroxylase activity in the hamster [Elektronische Daten] [Hitoshi Oda, Syoji Kuroki, Hiroyuki Yamashita, Fumio Nakayama] In order to investigate the effects of bile acid feeding on hepatic microsomal deoxycholate 7α-hydroxylase activity, three different bile acids were administered (0.2% w/w in chow) to hamsters for two weeks. Deoxycholate 7α-hydroxylase activity was increased markedly by feeding of cholic acid (CA) and slightly by deoxycholic acid (DCA) Chenodeoxycholic acid (CDCA) had little effect on the enzyme activity. Feeding each of the bile acids significantly inhibited the activity of cholesterol 7α-hydroxylase in the order CDCA≥ DCA>CA. There was no correlation between deoxycholate 7α-hydroxylase activity and cholesterol 7α-hydroxylase activity. It is concluded that the activity of deoxycholate 7α-hydroxylase is up-regulated by feeding DCA and CA and that the mechanism seems to be different from that of cholesterol 7α-hydroxylase. The increased activity of hepatic deoxycholate 7α-hydroxylase by CA and DCA should be beneficial in minimizing the toxic effects of DCA in the hamster. American Oil Chemists' Society, 1985 Oda Hitoshi Department of Surgery I, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, 812, Fukuoka, Japan aut Kuroki Syoji Department of Surgery I, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, 812, Fukuoka, Japan aut Yamashita Hiroyuki Department of Surgery I, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, 812, Fukuoka, Japan aut Nakayama Fumio Department of Surgery I, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, 812, Fukuoka, Japan aut Lipids Springer-Verlag 25/11(1990-11-01), 706-710 0024-4201 25:11<706 1990 25 11745 https://doi.org/10.1007/BF02544038 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02544038 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Oda Hitoshi Department of Surgery I, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, 812, Fukuoka, Japan aut NATIONALLICENCE 700 1- Kuroki Syoji Department of Surgery I, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, 812, Fukuoka, Japan aut NATIONALLICENCE 700 1- Yamashita Hiroyuki Department of Surgery I, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, 812, Fukuoka, Japan aut NATIONALLICENCE 700 1- Nakayama Fumio Department of Surgery I, Kyushu University Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, 812, Fukuoka, Japan aut NATIONALLICENCE 773 0- Lipids Springer-Verlag 25/11(1990-11-01), 706-710 0024-4201 25:11<706 1990 25 11745 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer