caa a22 4500 465766951 CHVBK 20180323111917.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00294243 doi (NATIONALLICENCE)springer-10.1007/BF00294243 Calcineurin and synaptophysin in the human spinal cord of normal individuals and patients with familial dysautonomia [Elektronische Daten] [S. Goto, A. Hirano, J. Pearson] Summary: This report concerns the immunohistochemical demonstration of two neuronal Ca2+-binding proteins, calcineurin and synaptophysin, in the spinal cord of normal controls and from patients with familial dysautonomia. In controls, calcineurin immunoreactivity was highly concentrated in small nerve cells and fibers of the substantia gelatinosa. Synaptophysin immunoreactivity was normally distributed throughout the spinal cord gray matter, being highly concentrated in the substantia gelatinosa, the dorsal nucleus of Clarke and the anterior horn. In patients with familial dysautonomia, no apparent changes in calcineurin immunoreactivity were found in the substantia gelatinosa. By contrast, there was a significant depletion of synaptophysin-positive axon terminals in the substantia gelatinosa and in the dorsal nucleus of Clarke of patients with familial dysautonomia. Springer-Verlag, 1990 Calcineurin nationallicence Synaptophysin nationallicence Familial dysautonomia nationallicence Spinal cord nationallicence Substantia gelatinosa nationallicence Goto S. Division of Neuropathology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA aut Hirano A. Division of Neuropathology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA aut Pearson J. Department of Pathology, New York University Medical Center, 10016, New York, NY, USA aut Acta Neuropathologica Springer-Verlag 79/6(1990-04-01), 647-652 0001-6322 79:6<647 1990 79 401 https://doi.org/10.1007/BF00294243 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00294243 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goto S. Division of Neuropathology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA aut NATIONALLICENCE 700 1- Hirano A. Division of Neuropathology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA aut NATIONALLICENCE 700 1- Pearson J. Department of Pathology, New York University Medical Center, 10016, New York, NY, USA aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 79/6(1990-04-01), 647-652 0001-6322 79:6<647 1990 79 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer