caa a22 4500 46576696X CHVBK 20180323111917.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00294247 doi (NATIONALLICENCE)springer-10.1007/BF00294247 Down's dyndrome and Alzheimer's disease: dendritic spine counts in the hippocampus [Elektronische Daten] [I. Ferrer, F. Gullotta] Summary: Samples of the hippocampus of four patients with Down's syndrome [two men aged 35 and 36 years with no evidence of Alzheimer's disease (AD) and two patients aged 47 and 55 years with associated AD] were obtained at post mortem and processed according to the rapid Golgi method. A significant reduction in the number of dendritic spines (DS) was found in the apical (middle, distal and oblique segments) and basilar (thick and thin segments) dendritic arbors of CA1 and CA2-3 pyramidal neurons in patients with Down's syndrome and no AD when compared to age-matched controls. An additional decrease of DS in every segment occurred in Down's patients with associated AD when compared to agematched controls and Down's patients with no AD. In Down's syndrome (either associated or not to AD) thin basilar dendrites were the most severely involved; in AD patients CA1 pyramids were more severely affected than pyramidal neurons of the CA2-3 subfield. Springer-Verlag, 1990 Down's syndrome nationallicence Alzheimer's disease nationallicence Hippocampus nationallicence Golgi method nationallicence Dendritic spines nationallicence Ferrer I. Unidad Neuropatología, Departamento Anatomía Patológica, Hospital Príncipes de España, Universidad Barcelona, E-08907, Hospitalet de Llobregat, Spain aut Gullotta F. Institut für Neuropathologie der Universität Münster, Domagkstrasse 17, D-4400, Münster, Germany aut Acta Neuropathologica Springer-Verlag 79/6(1990-04-01), 680-685 0001-6322 79:6<680 1990 79 401 https://doi.org/10.1007/BF00294247 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00294247 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ferrer I. Unidad Neuropatología, Departamento Anatomía Patológica, Hospital Príncipes de España, Universidad Barcelona, E-08907, Hospitalet de Llobregat, Spain aut NATIONALLICENCE 700 1- Gullotta F. Institut für Neuropathologie der Universität Münster, Domagkstrasse 17, D-4400, Münster, Germany aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 79/6(1990-04-01), 680-685 0001-6322 79:6<680 1990 79 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer