caa a22 4500 465767036 CHVBK 20180323111917.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00294234 doi (NATIONALLICENCE)springer-10.1007/BF00294234 Parkinson's disease: an immunohistochemical study of Lewy body-containing neurons in the enteric nervous system [Elektronische Daten] [K. Wakabayashi, H. Takahashi, E. Ohama, F. Ikuta] Summary: We performed immunohistochemical analysis of specimens from three autopsied patients with Parkinson's disease, using antibodies to tyrosine hydroxylase (TH), vasoactive intestinal polypeptide (VIP), somatostatin, met-enkephalin, leu-enkephalin and substance P in an attempt to reveal the types of neurons that contain Lewy bodies (LBs) in the paravertebral and celiac sympathetic ganglia and in the enteric nervous system of the alimentary tract. In the sympathetic ganglia, almost all LB-containing neuronal cell bodies and processes were immunoreactive for TH. In the alimentary tract, however, most LBs were found in the VIP-immunoreactive (VIP-IR) neuronal cell bodies and processes. In spite of the significant presence of TH-IR neuronal cell bodies and processes in the alimentary tract, LB-containing TH-IR neuronal elements were rarely encountered. These findings indicate that in the alimentary tract, the VIP neuron system is mainly involved in the disease process of Parkinson's disease. Springer-Verlag, 1990 Parkinson's disease nationallicence Lewy body nationallicence Enteric nervous system nationallicence Immunohistochemistry nationallicence Vasoactive intestinal polypeptide nationallicence Wakabayashi K. Department of Pathology, Brain Research Institute, Niigata University, 1 Asahimachi, 951, Niigata, Japan aut Takahashi H. Department of Pathology, Brain Research Institute, Niigata University, 1 Asahimachi, 951, Niigata, Japan aut Ohama E. Department of Pathology, Brain Research Institute, Niigata University, 1 Asahimachi, 951, Niigata, Japan aut Ikuta F. Department of Pathology, Brain Research Institute, Niigata University, 1 Asahimachi, 951, Niigata, Japan aut Acta Neuropathologica Springer-Verlag 79/6(1990-04-01), 581-583 0001-6322 79:6<581 1990 79 401 https://doi.org/10.1007/BF00294234 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00294234 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wakabayashi K. Department of Pathology, Brain Research Institute, Niigata University, 1 Asahimachi, 951, Niigata, Japan aut NATIONALLICENCE 700 1- Takahashi H. Department of Pathology, Brain Research Institute, Niigata University, 1 Asahimachi, 951, Niigata, Japan aut NATIONALLICENCE 700 1- Ohama E. Department of Pathology, Brain Research Institute, Niigata University, 1 Asahimachi, 951, Niigata, Japan aut NATIONALLICENCE 700 1- Ikuta F. Department of Pathology, Brain Research Institute, Niigata University, 1 Asahimachi, 951, Niigata, Japan aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 79/6(1990-04-01), 581-583 0001-6322 79:6<581 1990 79 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer