caa a22 4500 465767095 CHVBK 20180323111917.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00294246 doi (NATIONALLICENCE)springer-10.1007/BF00294246 Altered angioarchitecture in selected areas of brains with Alzheimer's disease [Elektronische Daten] [V. Fischer, A. Siddiqi, Y. Yusufaly] Summary: It was the aim of this study to determine, qualitatively and quantitatively, alterations in the blood vessels of brains removed postmortem from patients with Alzheimer's disease (AD), and to compare these findings with the appearance of cerebral blood vessels in a group of individuals without brain disorders. Celloidin sections of brain tissue from four cerebral areas, pre-frontal (Brodmann's area 9), basal forebrain, sensorimotor, and hippocampus, were subjected to an alkaline phosphatase reaction to facilitate the evaluation of the vascular distribution. The vascular density in five sections was determined by counting the number of vascular intersections with a microscopic test grid of 100 squares; ten fields per section were examined in this manner. Analysis of 16 AD and 6 control brains, showed that there was a striking and statistically significant reduction in the vascular net density specifically in the basal forebrain region and the hippocampus of AD brains. In addition, vessels in the AD brains exhibited extensive topographical changes, such as kinking and looping. These results indicate that modifications in vascular density are present in AD brains with a marked regional specificity. Springer-Verlag, 1990 Brain nationallicence Alzheimer's disease nationallicence Arterioles and capillaries nationallicence Alkaline phosphatase reaction nationallicence Vascular density nationallicence Fischer V. Department of Anatomy and Neurobiology, St. Louis University School of Medicine, 1402 S. Grand Blvd., 63104, St. Louis, MI, USA aut Siddiqi A. Department of Anatomy and Neurobiology, St. Louis University School of Medicine, 1402 S. Grand Blvd., 63104, St. Louis, MI, USA aut Yusufaly Y. Department of Neurology, St. Louis University School of Medicine, 1402 S. Grand Blvd., 63104, St. Louis, MI, USA aut Acta Neuropathologica Springer-Verlag 79/6(1990-04-01), 672-679 0001-6322 79:6<672 1990 79 401 https://doi.org/10.1007/BF00294246 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00294246 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fischer V. Department of Anatomy and Neurobiology, St. Louis University School of Medicine, 1402 S. Grand Blvd., 63104, St. Louis, MI, USA aut NATIONALLICENCE 700 1- Siddiqi A. Department of Anatomy and Neurobiology, St. Louis University School of Medicine, 1402 S. Grand Blvd., 63104, St. Louis, MI, USA aut NATIONALLICENCE 700 1- Yusufaly Y. Department of Neurology, St. Louis University School of Medicine, 1402 S. Grand Blvd., 63104, St. Louis, MI, USA aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 79/6(1990-04-01), 672-679 0001-6322 79:6<672 1990 79 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer