caa a22 4500 465767141 CHVBK 20180323111917.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00308712 doi (NATIONALLICENCE)springer-10.1007/BF00308712 Relative growth and maturation of axon size and myelin thickness in the tibial nerve of the rat [Elektronische Daten] 1. Normal animals [J. Fraher, D. O'Leary, M. Moran, M. Cole, R. King, P. Thomas] Summary: Morphometric observations have been made on the medial plantar division of the tibial nerve (MPD) and on the motor branches of the tibial nerve to the calf muscles (MBC) in rats ranging in age from weaning (3 weeks) to 12 months. Axon size, assessed by measurements of circumference and cross-sectional area, increased rapidly until 3 months with further slight increases between 3 and 9 months and a slight fall between 9 and 12 months. Axon size distributions were unimodal throughout in the MPD but bimodal for the MBC except at 3 weeks. Distributions of myelin thickness were bimodal throughout for both nerves. Scatter plots of g ratios (axon diameter: total fibre diameter) confirmed the presence of two fibre populations: a group of small fibres with relatively thin myelin sheaths, and a group of larger fibres within which sheath thickness was relatively less on the larger than on the smaller axons. These two fibres populations were less easily separable in the MBC than in the MPD nerves. These results document morphometrically the normal growth changes in the rat tibial nerve and also provide control data for the analysis of the effects of experimental procedures on the growth and maturation of peripheral nerve fibres. Springer-Verlag, 1990 Peripheral nerve morphometry nationallicence Axons nationallicence Myelin nationallicence Growth changes nationallicence Fraher J. Department of Anatomy, University College, Cork, Ireland aut O'Leary D. Department of Anatomy, University College, Cork, Ireland aut Moran M. Department of Statistics, University College, Cork, Ireland aut Cole M. Department of Statistics, University College, Cork, Ireland aut King R. Department of Neurological Science, Royal Free Hospital School of Medicine, Rowland Hill Street, NW 3 2PF, London, Great Britain aut Thomas P. Department of Neurological Science, Royal Free Hospital School of Medicine, Rowland Hill Street, NW 3 2PF, London, Great Britain aut Acta Neuropathologica Springer-Verlag 79/4(1990-01-01), 364-374 0001-6322 79:4<364 1990 79 401 https://doi.org/10.1007/BF00308712 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00308712 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fraher J. Department of Anatomy, University College, Cork, Ireland aut NATIONALLICENCE 700 1- O'Leary D. Department of Anatomy, University College, Cork, Ireland aut NATIONALLICENCE 700 1- Moran M. Department of Statistics, University College, Cork, Ireland aut NATIONALLICENCE 700 1- Cole M. Department of Statistics, University College, Cork, Ireland aut NATIONALLICENCE 700 1- King R. Department of Neurological Science, Royal Free Hospital School of Medicine, Rowland Hill Street, NW 3 2PF, London, Great Britain aut NATIONALLICENCE 700 1- Thomas P. Department of Neurological Science, Royal Free Hospital School of Medicine, Rowland Hill Street, NW 3 2PF, London, Great Britain aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 79/4(1990-01-01), 364-374 0001-6322 79:4<364 1990 79 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer