caa a22 4500 465767168 CHVBK 20180323111917.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00308715 doi (NATIONALLICENCE)springer-10.1007/BF00308715 Lundh B. Karolinska Institute, Department of Pathology (Neuropathology), Huddinge Hospital, S-14186, Huddinge, Sweden aut Spread of vesicular stomatitis virus along the visual pathways after retinal infection in the mouse [Elektronische Daten] [B. Lundh] Summary: Vesicular stomatitis virus (VSV) was injected into the left eyeball of 3-week-old mice and it infected the retinal ganglion cells. The infection spread rapidly along the visual pathways to the postsynaptic neurons in the contralateral superior collicle (SC) and lateral geniculate body (LGB). The distributional pattern of the viral immunoreactivity indicated an anterograde axonal transport of the infectious material. A subsequent spread to the ganglion cells of the right retina further indicated retrograde axonal VSV transport. Within the retina the infection spread from the ganglion cells to the pigment epithelium. Although a transneuronal spread of the VSV infection was observed, no VSV budding from or uptake in synaptic membranes was demonstrated ultrastructurally in the retina or the superior collicle. In the retina virions budded from the perikaryal and dendritic plasma membranes of the ganglion cells as well as from the nerve cell bodies of the inner and outer nuclear layers, but not from the receptor segments. In the superior collicle budding was also observed from the plasma membranes of nerve cell bodies and dendrites. In contrast, the intraocular injection of Sendai virus caused a limited retinal ganglion cell infection, with no further propagation in the retina or to the SC or LGB. Springer-Verlag, 1990 Vesicular stomatitis virus nationallicence Axonal transport nationallicence Visual system nationallicence Mouse nationallicence Acta Neuropathologica Springer-Verlag 79/4(1990-01-01), 395-401 0001-6322 79:4<395 1990 79 401 https://doi.org/10.1007/BF00308715 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00308715 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Lundh B. Karolinska Institute, Department of Pathology (Neuropathology), Huddinge Hospital, S-14186, Huddinge, Sweden aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 79/4(1990-01-01), 395-401 0001-6322 79:4<395 1990 79 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer