caa a22 4500 465767176 CHVBK 20180323111917.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00308716 doi (NATIONALLICENCE)springer-10.1007/BF00308716 Phosphorylated high molecular weight neurofilament protein in lower motor neurons in amyotrophic lateral sclerosis and other neurodegenerative diseases involving ventral horn cells [Elektronische Daten] [G. Sobue, Y. Hashizume, T. Yasuda, E. Mukai, T. Kumagai, T. Mitsuma, J. Trojanowski] Summary: Lower motor neurons of the spinal cord of patients with amyotrophic lateral sclerosis (ALS), Werdnig-Hoffmann's disease (WH), X-linked recessive bulbospinal neuronopathy (X-BSNP) and multiple system atrophy (MSA), all of which were known to involve the lower motor neurons, were immunohistochemically examined by using a monoclonal antibody (Ta-51) specific to phosphorylated epitopes of high molecular weight subunits of neurofilaments. The incidence of Ta-51-positive neurons was significantly increased in ALS, WH and MSA, but not in X-BSNP. Ta-51-positive neurons showed a wide variety of morphological appearances, including neurons with normal appearance, central chromatolysis, simple atrophy and neurons containing massive neurofilamentous accumulation. In aged-control cases, similar Ta-51-positive neurons were observed, although to a much lesser extent. In ALS, spheroids and globules, which were strongly positive for Ta-51, were also significantly increased. Ta-51-positive motor neurons, spheroids and globules appeared in proportional to the number of remaining large motor neurons in ALS. Springer-Verlag, 1990 Phosphorylated high molecular weight neurofilament nationallicence Motor neuron nationallicence Amyotrophic lateral sclerosis (ALS) nationallicence Werdnig-Hoffmann's disease nationallicence X-linked recessive bulbospinal neuronopathy nationallicence Sobue G. Division of Neurology, Fourth Department of Internal Medicine, Aichi Medical University, 480-11, Nagakute, Aichi, Japan aut Hashizume Y. Department of Pathology, Nagoya University, School of Medicine, Nagoya, Japan aut Yasuda T. Department of Neurology, Nagoya University, School of Medicine, Nagoya, Japan aut Mukai E. Department of Neurology, National Nagoya Hospital, Nagoya, Japan aut Kumagai T. Department of Child Neurology, Aichi Prefectural Colony Hospital, Nagoya, Japan aut Mitsuma T. Division of Neurology, Fourth Department of Internal Medicine, Aichi Medical University, 480-11, Nagakute, Aichi, Japan aut Trojanowski J. Department of Pathology and Laboratory Medicine, University of Pennsylvania, School of Medicine, Philadelphia, USA aut Acta Neuropathologica Springer-Verlag 79/4(1990-01-01), 402-408 0001-6322 79:4<402 1990 79 401 https://doi.org/10.1007/BF00308716 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00308716 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sobue G. Division of Neurology, Fourth Department of Internal Medicine, Aichi Medical University, 480-11, Nagakute, Aichi, Japan aut NATIONALLICENCE 700 1- Hashizume Y. Department of Pathology, Nagoya University, School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Yasuda T. Department of Neurology, Nagoya University, School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Mukai E. Department of Neurology, National Nagoya Hospital, Nagoya, Japan aut NATIONALLICENCE 700 1- Kumagai T. Department of Child Neurology, Aichi Prefectural Colony Hospital, Nagoya, Japan aut NATIONALLICENCE 700 1- Mitsuma T. Division of Neurology, Fourth Department of Internal Medicine, Aichi Medical University, 480-11, Nagakute, Aichi, Japan aut NATIONALLICENCE 700 1- Trojanowski J. Department of Pathology and Laboratory Medicine, University of Pennsylvania, School of Medicine, Philadelphia, USA aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 79/4(1990-01-01), 402-408 0001-6322 79:4<402 1990 79 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer