caa a22 4500 465767184 CHVBK 20180323111917.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00308718 doi (NATIONALLICENCE)springer-10.1007/BF00308718 Localization of basic fibroblast growth factor, a mitogen and angiogenic factor, in human brain tumors [Elektronische Daten] [W. Paulus, C. Grothe, M. Sensenbrenner, T. Janet, I. Baur, M. Graf, W. Roggendorf] Summary: Fibroblast growth factor (FGF) is a potent angiogenic factor and a mitogen for a variety of mesoderm-and neuroectoderm-derived cell types (e.g., fibroblasts, endothelial cells, astrocytes, oligodendrocytes). After application of a monospecific polyclonal antiserum, we localized basic FGF on frozen sections of 73 human brain tumors using immunohisto-chemistry. FGF was present in a variable number of tumor cells (16/16 astrocytomas, 5/5 ependymomas, 0/3 benign and 4/7 anaplastic oligodendrogliomas, 11/12 glioblastomas, 11/11 meningiomas, 6/6 neurilemmomas, 0/3 pituitary adenomas, 2/2 choroid plexus papillomas, 0/1 neurocytoma, 2/2 benign fibrous histiocytomas, 2/5 metastatic carcinomas). FGF was detected in vascular cells of 59 tumors and in fibroblasts of connective tissue stroma from all papillomas and metastases. These results tend to indicate FGF involvement in the malignant progression of gliomas due to an autocrine or paracrine action. Histopathological aspects of malignant gliomas (e.g., pseudopalisading or pathological vessels) could be related to FGF activity. Springer-Verlag, 1990 Fibroblast growth factor (FGF) nationallicence Basic FGF nationallicence Angiogenesis nationallicence Brain tumors nationallicence Immunohistochemistry nationallicence Paulus W. Institut für Hirnforschung, Universität Tübingen, Federal Republic of Germany aut Grothe C. Institut für Anatomie und Zellbiologie, Universität Marburg, Federal Republic of Germany aut Sensenbrenner M. Centre de Neurochimie du C.N.R.S., Strasbourg, France aut Janet T. Centre de Neurochimie du C.N.R.S., Strasbourg, France aut Baur I. Institut für Hirnforschung, Universität Tübingen, Federal Republic of Germany aut Graf M. Institut für Hirnforschung, Universität Tübingen, Federal Republic of Germany aut Roggendorf W. Institut für Hirnforschung, Universität Tübingen, Federal Republic of Germany aut Acta Neuropathologica Springer-Verlag 79/4(1990-01-01), 418-423 0001-6322 79:4<418 1990 79 401 https://doi.org/10.1007/BF00308718 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00308718 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Paulus W. Institut für Hirnforschung, Universität Tübingen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Grothe C. Institut für Anatomie und Zellbiologie, Universität Marburg, Federal Republic of Germany aut NATIONALLICENCE 700 1- Sensenbrenner M. Centre de Neurochimie du C.N.R.S., Strasbourg, France aut NATIONALLICENCE 700 1- Janet T. Centre de Neurochimie du C.N.R.S., Strasbourg, France aut NATIONALLICENCE 700 1- Baur I. Institut für Hirnforschung, Universität Tübingen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Graf M. Institut für Hirnforschung, Universität Tübingen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Roggendorf W. Institut für Hirnforschung, Universität Tübingen, Federal Republic of Germany aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 79/4(1990-01-01), 418-423 0001-6322 79:4<418 1990 79 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer