caa a22 4500 465767249 CHVBK 20180323111917.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00308713 doi (NATIONALLICENCE)springer-10.1007/BF00308713 Relative growth and maturation of axin size and myelin thickness in the tibial nerve of the rat [Elektronische Daten] 2. Effect of streptozotocin-induced diabetes [P. Thomas, J. Fraher, D. O'Leary, M. Moran, M. Cole, R. King] Summary: The relative changes in the growth and maturation of axon size and myelin thickness were studied in the medial plantar division of the tibial nerve in the lower leg and in the motor branches of the tibial nerve to the calf muscles in rats in which diabetes mellitus had been induced with streptozotocin at the time of weaning. Observations were made at 6 weeks and 3, 6, 9 and 12 months of diabetes for comparison with age-matched controls. Similar changes were observed in both nerves. Growth in body weight and skeletal growth was severely retarded from the time of induction of diabetes but at the 6-week stage axon size was not reduced, suggesting that neural growth may initially be relatively protected. At later stages axon size was consistently reduced in the diabetic animals as compared with the controls and showed an absolute reduction at 12 months, as compared with 9 months, that was greater than in the controls. Myelin thickness became reduced earlier and was more severely affected than axon size so that the fibers were relatively hypomyelinated. The myelin changes were greater in larger than in smaller fibers. The index of circularity of axons was reduced in the diabetic nerves. These results show that induction of diabetes in prepubertal rats produces effects on peripheral nerve fibers which differ from those resulting from diabetes induced in adult animals. The effects also differ between large and small nerve fibres. These observations may explain some of the disparate findings obstained in previous studies on experimental diabetes in rats. Springer-Verlag, 1990 Peripheral nerve nationallicence Morphometry nationallicence Diabetes mellitus nationallicence Hypomyelination nationallicence Thomas P. Department of Neurological Science, Royal Free Hospital School of Medicine, Rowland Hill Street, NW3 2PF, London, Great Britain aut Fraher J. Department of Anatomy, University College, Cork, Ireland aut O'Leary D. Department of Anatomy, University College, Cork, Ireland aut Moran M. Department of Statistics, University College, Cork, Ireland aut Cole M. Department of Statistics, University College, Cork, Ireland aut King R. Department of Statistics, University College, Cork, Ireland aut Acta Neuropathologica Springer-Verlag 79/4(1990-01-01), 375-386 0001-6322 79:4<375 1990 79 401 https://doi.org/10.1007/BF00308713 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00308713 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Thomas P. Department of Neurological Science, Royal Free Hospital School of Medicine, Rowland Hill Street, NW3 2PF, London, Great Britain aut NATIONALLICENCE 700 1- Fraher J. Department of Anatomy, University College, Cork, Ireland aut NATIONALLICENCE 700 1- O'Leary D. Department of Anatomy, University College, Cork, Ireland aut NATIONALLICENCE 700 1- Moran M. Department of Statistics, University College, Cork, Ireland aut NATIONALLICENCE 700 1- Cole M. Department of Statistics, University College, Cork, Ireland aut NATIONALLICENCE 700 1- King R. Department of Statistics, University College, Cork, Ireland aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 79/4(1990-01-01), 375-386 0001-6322 79:4<375 1990 79 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer