caa a22 4500 465767273 CHVBK 20180323111918.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF00296111 doi (NATIONALLICENCE)springer-10.1007/BF00296111 Acute response of the fetal telencephalon to short-term maternal exposure to ethanol in the rat [Elektronische Daten] [L. Kotkoskie, S. Norton] Summary: Pregnant rats were exposed to either ethanol (total dose 18 g/kg) on gestational days 14 and 15 or whole-body ionizing radiation (0.5 Gy) on gestational day 15. On gestational day 16, 24 h following the last dose of ethanol or exposure to ionizing radiation, the developing cerebral cortex of the fetus was examined histologically. Ionizing radiation caused extensive cell death within the fetal cerebral cortex whereas ethanol caused more subtle morphological changes such as cortical thinning and petechial intraventricular hemorrhages. These findings suggest that ethanol, unlike ionizing radiation, acts by some mechanism other than cell death to cause cortical thinning and cortical malformations. The pathogenesis of ethanol-induced cortical dysgenesis may include fetal hypoxia and inhibition of neuroblast proliferation within the developing cerebral cortex. Springer-Verlag, 1990 Fetal alcohol syndrome nationallicence Ethanol nationallicence Ionizing radiation nationallicence Cerebral cortex nationallicence Kotkoskie L. Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 39th Street and Rainbow Blvd., 66103, Kansas City, KS, USA aut Norton S. Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 39th Street and Rainbow Blvd., 66103, Kansas City, KS, USA aut Acta Neuropathologica Springer-Verlag 79/5(1990-02-01), 513-519 0001-6322 79:5<513 1990 79 401 https://doi.org/10.1007/BF00296111 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00296111 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kotkoskie L. Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 39th Street and Rainbow Blvd., 66103, Kansas City, KS, USA aut NATIONALLICENCE 700 1- Norton S. Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 39th Street and Rainbow Blvd., 66103, Kansas City, KS, USA aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 79/5(1990-02-01), 513-519 0001-6322 79:5<513 1990 79 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer