caa a22 4500 465767281 CHVBK 20180323111918.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF00296107 doi (NATIONALLICENCE)springer-10.1007/BF00296107 Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer's disease [Elektronische Daten] [D. Dickson, A. Wertkin, L. Mattiace, E. Fier, Y. Kress, P. Davies, S. Yen] Summary: Senile plaques are present in the cerebellum of most Alzheimer patients. They are composed of beta-amyloid deposits lacking neurites detectable with immunocytochemistry for neurofilament, tau and paired helical filament proteins. Recent studies, however, have shown that cerebellar plaques usually contain round structures that are reactive with ubiquitin antibodies. In this immunoelectron microscopic study, the nature of these structures is explored. Ubiquitin-positive structures in cerebellar senile plaques were composed of degenerating neurites that contained membranous and vesicular dense bodies, but no paired helical filaments. A minority of the neurites contained finely granular material. Thus, cerebellar plaques are associated with neuritic degeneration, and the neurites in cerebellar plaques resemble dystrophic neurites in senile plaques of non-demented elderly subjects and subjects with non-Alzheimer dementias. They differ from some of the neurites in senile plaques in the neocortex in Alzheimer's disease by the absence of paired helical filaments. These results suggest that the same mechanisms involved in the generation of dystrophic neurites in pathological aging are involved in generating dystrophic neurites in the cerebellum in Alzheimer's discase. Springer-Verlag, 1990 Senile plaques nationallicence Alzheimer's disease nationallicence Ubiquitin nationallicence Immunoelectron microscopy nationallicence Neuritic degeneration nationallicence Dickson D. Department of Pathology (Neuropathology), K-438, The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut Wertkin A. Department of Pathology (Neuropathology), K-438, The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut Mattiace L. Department of Pathology (Neuropathology), K-438, The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut Fier E. Department of Pathology (Neuropathology), K-438, The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut Kress Y. Department of Pathology (Neuropathology), K-438, The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut Davies P. Department of Pathology (Neuropathology), K-438, The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut Yen S. Department of Pathology (Neuropathology), K-438, The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut Acta Neuropathologica Springer-Verlag 79/5(1990-02-01), 486-493 0001-6322 79:5<486 1990 79 401 https://doi.org/10.1007/BF00296107 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00296107 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dickson D. Department of Pathology (Neuropathology), K-438, The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut NATIONALLICENCE 700 1- Wertkin A. Department of Pathology (Neuropathology), K-438, The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut NATIONALLICENCE 700 1- Mattiace L. Department of Pathology (Neuropathology), K-438, The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut NATIONALLICENCE 700 1- Fier E. Department of Pathology (Neuropathology), K-438, The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut NATIONALLICENCE 700 1- Kress Y. Department of Pathology (Neuropathology), K-438, The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut NATIONALLICENCE 700 1- Davies P. Department of Pathology (Neuropathology), K-438, The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut NATIONALLICENCE 700 1- Yen S. Department of Pathology (Neuropathology), K-438, The Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 79/5(1990-02-01), 486-493 0001-6322 79:5<486 1990 79 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer