caa a22 4500 465767311 CHVBK 20180323111918.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF00296106 doi (NATIONALLICENCE)springer-10.1007/BF00296106 Three-dimensional structure of Alzheimer's neurofibrillary tangles of the aged human brain revealed by the quick-freeze, deep-etch and replica method [Elektronische Daten] [K. Ohtsubo, N. Izumiyama, H. Shimada, T. Tachikawa, H. Nakamura] Summary: The three-dimensional structure of Alzheimer's neurofibrillary tangles in the pyramidal cells of the hippocampus and in the nerve cells of the parahippocampal gyrus was examined by the quick-freeze, deep-etch and replica method. The tangles consisted of either parallel bundles of or randomly arranged paired helical filaments (PHF), occupying the perikaryotic cytoplasm and extending to the dendritic processes. On the stereophotographs the PHF, measuring 28 to 36 nm in width, had two component filaments of 14 to 18 nm in diameter which were coiled anti-clockwise (left-handed) around each other with periodicity of 70 to 90 nm. The PHF in compact parallel bundles were cross-linked to each other with thin filaments, of about 6 nm in diameter, at relatively regular intervals. Randomly arranged PHF had no cross-bridges or side arms. Straight-type tangles of about 24 nm in diameter were rarely found in the dendritic processes. There were no discernible differences between the PHF of the patients with senile dementia of Alzheimer type and those of nondemented brains. Springer-Verlag, 1990 Alzheimer's tangle nationallicence Paired helical filaments nationallicence Interfilamentous cross-linking bridge nationallicence Quick-freeze, deep-etch and replica nationallicence Ohtsubo K. Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, 35-2, Sakaecho, Itabashiku, 173, Tokyo, Japan aut Izumiyama N. Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, 35-2, Sakaecho, Itabashiku, 173, Tokyo, Japan aut Shimada H. Division of Pathology, Tokyo Metropolitan Geriatric Hospital, 35-2, Sakaecho, Itabashiku, 173, Tokyo, Japan aut Tachikawa T. Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, 35-2, Sakaecho, Itabashiku, 173, Tokyo, Japan aut Nakamura H. Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, 35-2, Sakaecho, Itabashiku, 173, Tokyo, Japan aut Acta Neuropathologica Springer-Verlag 79/5(1990-02-01), 480-485 0001-6322 79:5<480 1990 79 401 https://doi.org/10.1007/BF00296106 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00296106 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ohtsubo K. Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, 35-2, Sakaecho, Itabashiku, 173, Tokyo, Japan aut NATIONALLICENCE 700 1- Izumiyama N. Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, 35-2, Sakaecho, Itabashiku, 173, Tokyo, Japan aut NATIONALLICENCE 700 1- Shimada H. Division of Pathology, Tokyo Metropolitan Geriatric Hospital, 35-2, Sakaecho, Itabashiku, 173, Tokyo, Japan aut NATIONALLICENCE 700 1- Tachikawa T. Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, 35-2, Sakaecho, Itabashiku, 173, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakamura H. Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, 35-2, Sakaecho, Itabashiku, 173, Tokyo, Japan aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 79/5(1990-02-01), 480-485 0001-6322 79:5<480 1990 79 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer