caa a22 4500 465767354 CHVBK 20180323111918.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF00296114 doi (NATIONALLICENCE)springer-10.1007/BF00296114 Occurrence of diffuse amyloid deposits in the presubicular parvopyramidal layer in Alzheimer's disease [Elektronische Daten] [H. Akiyama, H. Tago, S. Itagaki, P. McGeer] Summary: Silver staining by a modified Bielschowsky's technique and immunostaining for β-amyloid protein BAP have revealed the occurrence of diffuse amyloid deposits bilaterally in the presubiculum in each of fourteen Alzheimer's disease cases examined. Observations on serial blocks show these deposits to be localized in the parvopyramidal layer of the presubiculum proper and the transsubiculum. They are also observed in the cellular islands within the molecular layer of the subiculum but not in the parasubiculum. These amyloid deposits are not accompanied by neurofibrillary tangles, neuropil threads, or the aggregated microglial reaction which is characteristically associated with classic senile plaques. Convergence of input from limbic and cortical areas might play a significant role in the formation of these diffuse amyloid deposits. Springer-Verlag, 1990 Diffuse amyloid deposits nationallicence Alzheimer's nationallicence Presubiculum nationallicence Akiyama H. Department of Psychiatry, Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, V6T 1W5, Vancouver, BC, Canada aut Tago H. Department of Neuropsychiatry, Fukushima Medical College, 960, Fukushima-shi, Japan aut Itagaki S. Department of Psychiatry, Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, V6T 1W5, Vancouver, BC, Canada aut McGeer P. Department of Psychiatry, Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, V6T 1W5, Vancouver, BC, Canada aut Acta Neuropathologica Springer-Verlag 79/5(1990-02-01), 537-544 0001-6322 79:5<537 1990 79 401 https://doi.org/10.1007/BF00296114 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00296114 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Akiyama H. Department of Psychiatry, Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, V6T 1W5, Vancouver, BC, Canada aut NATIONALLICENCE 700 1- Tago H. Department of Neuropsychiatry, Fukushima Medical College, 960, Fukushima-shi, Japan aut NATIONALLICENCE 700 1- Itagaki S. Department of Psychiatry, Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, V6T 1W5, Vancouver, BC, Canada aut NATIONALLICENCE 700 1- McGeer P. Department of Psychiatry, Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, V6T 1W5, Vancouver, BC, Canada aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 79/5(1990-02-01), 537-544 0001-6322 79:5<537 1990 79 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer